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CREB-binding protein

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<scene name='54/541099/Cv/6'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref>
<scene name='54/541099/Cv/6'>Acetyllysine binding site</scene> with chain B ([[3p1c]]).<ref>PMID:22464331</ref>
 +
 +
== 3D Structures of CREB-binding protein ==
 +
[[CREB-binding protein 3D structures]]
 +
</StructureSection>
</StructureSection>
== 3D Structures of CREB-binding protein ==
== 3D Structures of CREB-binding protein ==
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*CBP
+
*CBP domains – BZIP 283-341; zinc finger 376-400; KIX 587-673; bromodomain 1081-1197; ZZ 1699-1751; TAZ2 1763-1854
-
**[[4i9o]] – mCBP GACKIX domain (mutant) - mouse <br />
+
**[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
 +
**[[2d82]] – hCBP bromodomain - NMR<br />
 +
**[[3dwy]], [[4ouf]], [[4whu]] – hCBP bromodomain <br />
 +
**[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]], [[4tqn]], [[4ts8]], [[4yk0]], [[5cgp]], [[5dbm]], [[5eic]], [[5eng]], [[5ep7]], [[5h85]], [[5i83]], [[5i86]], [[5i89]], [[5i8b]], [[5i8g]], [[5j0d]], [[5ktu]], [[5ktw]], [[5ktx]], [[5tb6]] – hCBP bromodomain + inhibitor<br />
 +
**[[2l84]], [[2l85]] – hCBP bromodomain + inhibitor - NMR<br />**[[4i9o]] – mCBP GACKIX domain (mutant) - mouse <br />
**[[1f81]] – mCBP TAZ2 domain - NMR <br />
**[[1f81]] – mCBP TAZ2 domain - NMR <br />
**[[1u2n]] – mCBP TAZ1 domain - NMR <br />
**[[1u2n]] – mCBP TAZ1 domain - NMR <br />
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**[[1tot]] – mCBP ZZ domain – NMR <br />
**[[1tot]] – mCBP ZZ domain – NMR <br />
**[[2kkj]] – mCBP nuclear coactivator binding domain - NMR <br />
**[[2kkj]] – mCBP nuclear coactivator binding domain - NMR <br />
-
**[[1wo3]], [[1wo4]], [[1wo5]], [[1wo6]], [[1wo7]] – hCBP zinc finger domain (mutant) – human - NMR <br />
 
-
**[[2d82]] – hCBP bromodomain - NMR<br />
 
-
**[[3dwy]], [[4ouf]], [[4whu]] – hCBP bromodomain <br />
 
-
**[[3p1c]], [[3p1d]], [[3p1e]], [[3p1f]], [[3svh]], [[4a9k]], [[4tqn]], [[4ts8]], [[4yk0]], [[5cgp]], [[5dbm]], [[5eic]], [[5eng]], [[5ep7]], [[5h85]], [[5i83]], [[5i86]], [[5i89]], [[5i8b]], [[5i8g]], [[5j0d]], [[5ktu]], [[5ktw]], [[5ktx]], [[5tb6]] – hCBP bromodomain + inhibitor<br />
 
-
**[[2l84]], [[2l85]] – hCBP bromodomain + inhibitor - NMR<br />
 
*CBP complex with protein
*CBP complex with protein
-
**[[1kbh]] – hCBP + nuclear receptor coactivator - NMR <br />
 
**[[1zoq]] – hCBP + interferon regulatory factor 3 <br />
**[[1zoq]] – hCBP + interferon regulatory factor 3 <br />
 +
**[[2n1a]] – hCBP + small ubiquitin-related modifier - NMR<br />
 +
**[[5jem]] – hCBP residues 2065-2111 + interferon-3<br />
 +
**[[2kje]] – hCBP TAZ2 domain + adenoviral E1A peptide - NMR<br />
 +
**[[1jsp]] – hCBP bromodomain + p53 peptide - NMR<br />
 +
**[[2kwf]] – hCBP KIX domain + transcription factor 4 – NMR <br />
 +
**[[2lxs]], [[2lxt]] – hCBP KIX domain + histone methyltransferase MLL peptide – NMR <br />
 +
**[[2rny]] – hCBP bromodomain + histone H3 peptide - NMR<br />
 +
**[[4n3w]], [[4n4f]] - hCBP bromodomain + histone H4 peptide <br />
 +
**[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain + ligand<br />
 +
**[[5zko]] – hCBP BZIP domain + CREB-regulated transcription coactivator + DNA <br />
 +
**[[5zk1]] – hCBP BZIP domain (mutant) + CREB-regulated transcription coactivator + DNA <br />
 +
**[[1kbh]] – mCBP + nuclear receptor coactivator - NMR <br />
**[[2c52]] – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR<br />
**[[2c52]] – mCBP residues 2059-2117 + nuclear receptor coactivator - NMR<br />
**[[1r8u]] – mCBP TAZ1 domain + P300-interacting transactivator - NMR <br />
**[[1r8u]] – mCBP TAZ1 domain + P300-interacting transactivator - NMR <br />
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**[[2ka6]] – mCBP TAZ2 domain + STAT1-TAD - NMR<br />
**[[2ka6]] – mCBP TAZ2 domain + STAT1-TAD - NMR<br />
**[[2ka4]] – mCBP TAZ2 domain + STAT2-TAD - NMR<br />
**[[2ka4]] – mCBP TAZ2 domain + STAT2-TAD - NMR<br />
-
**[[2n1a]] – hCBP + small ubiquitin-related modifier - NMR<br />
 
-
**[[5jem]] – hCBP residues 2065-2111 + interferon-3<br />
 
**[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />
**[[1kdx]] – mCBP KIX domain + CREB kinase inducible domain - NMR<br />
-
**[[2kje]] – hCBP TAZ2 domain + adenoviral E1A peptide - NMR<br />
 
-
**[[1jsp]] – hCBP bromodomain + p53 peptide - NMR<br />
 
**[[2l14]] – mCBP nuclear coactivator binding domain + p53 peptide - NMR<br />
**[[2l14]] – mCBP nuclear coactivator binding domain + p53 peptide - NMR<br />
**[[1sb0]] – mCBP KIX domain + protein c-Myb – NMR <br />
**[[1sb0]] – mCBP KIX domain + protein c-Myb – NMR <br />
**[[2agh]] – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR <br />
**[[2agh]] – mCBP KIX domain + protein c-Myb + zinc finger protein HRX – NMR <br />
**[[2lqh]], [[2lqi]] – mCBP KIX domain + forkhead box O3 – NMR <br />
**[[2lqh]], [[2lqi]] – mCBP KIX domain + forkhead box O3 – NMR <br />
-
**[[2kwf]] – hCBP KIX domain + transcription factor 4 – NMR <br />
+
 
-
**[[2lxs]], [[2lxt]] – hCBP KIX domain + histone methyltransferase MLL peptide – NMR <br />
+
-
**[[2rny]] – hCBP bromodomain + histone H3 peptide - NMR<br />
+
-
**[[4n3w]], [[4n4f]] - hCBP bromodomain + histone H4 peptide <br />
+
-
**[[4nr4]], [[4nr5]], [[4nr6]], [[4nr7]], [[4nyv]], [[4nyw]], [[4nyx]]- hCBP bromodomain + ligand<br />
+
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:17, 19 May 2019

Human CREB-binding protein with acetyllysine complex with SCN- and K+ (purple) ions 3p1c

Drag the structure with the mouse to rotate

3D Structures of CREB-binding protein

Updated on 19-May-2019

References

  1. ↑ Chrivia JC, Kwok RP, Lamb N, Hagiwara M, Montminy MR, Goodman RH. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature. 1993 Oct 28;365(6449):855-9. PMID:8413673 doi:http://dx.doi.org/10.1038/365855a0
  2. ↑ Petrij F, Giles RH, Dauwerse HG, Saris JJ, Hennekam RC, Masuno M, Tommerup N, van Ommen GJ, Goodman RH, Peters DJ, et al.. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature. 1995 Jul 27;376(6538):348-51. PMID:7630403 doi:http://dx.doi.org/10.1038/376348a0
  3. ↑ Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell. 2012 Mar 30;149(1):214-31. PMID:22464331 doi:10.1016/j.cell.2012.02.013

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Michal Harel, Alexander Berchansky

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