Hyaluronidase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
| - | HU structure contains an <scene name='49/497055/Cv/ | + | HU structure contains an <scene name='49/497055/Cv/8'>N-terminal, linker and C-terminal domains</scene>. The active site is in a cleft in the N-terminal domain. Two HUA molecules are bound in the active site making contacts with some HU residues and multiple contacts with water molecules<ref>PMID:10843845</ref>. |
| - | <scene name='49/497055/Cv/ | + | <scene name='49/497055/Cv/9'>1st active site of HU</scene>. Water molecules are shown as red spheres. |
| - | <scene name='49/497055/Cv/ | + | <scene name='49/497055/Cv/10'>2nd active site of HU</scene>. |
| - | <scene name='49/497055/Cv/ | + | <scene name='49/497055/Cv/11'>Dimethylarsinate binding site</scene>. |
</StructureSection> | </StructureSection> | ||
Revision as of 12:57, 19 May 2019
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3D structures of hyaluronidase
Updated on 19-May-2019
Reference
- ↑ Chao KL, Muthukumar L, Herzberg O. Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis. Biochemistry. 2007 Jun 12;46(23):6911-20. Epub 2007 May 16. PMID:17503783 doi:10.1021/bi700382g
- ↑ Ponnuraj K, Jedrzejas MJ. Mechanism of hyaluronan binding and degradation: structure of Streptococcus pneumoniae hyaluronate lyase in complex with hyaluronic acid disaccharide at 1.7 A resolution. J Mol Biol. 2000 Jun 16;299(4):885-95. PMID:10843845 doi:10.1006/jmbi.2000.3817
Created with the participation of Osnat Herzberg, Eran Hodis, Joel L. Sussman, Jaime Prilusky.
