Cryptochrome
From Proteopedia
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The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer<ref>PMID:22778400</ref>. | The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer<ref>PMID:22778400</ref>. | ||
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| + | == 3D Structures of cryptochrome == | ||
| + | [[Cryptochrome 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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[[3fy4]] – AtCry 6-4 + FAD <br /> | [[3fy4]] – AtCry 6-4 + FAD <br /> | ||
[[1np7]] – Cry - ''Synechocystis'' <br /> | [[1np7]] – Cry - ''Synechocystis'' <br /> | ||
| + | [[6fn3]], [[5zm0]] – CrCry + FAD – ''Chlamydomonas reinhardtii''<br /> | ||
| + | [[6fn2]] – CrCry + FAD + alloxazine derivative <br /> | ||
| + | [[6fn0]] – CrCry + FAD + DNA + pyrimidine derivative <br /> | ||
== References == | == References == | ||
Revision as of 06:39, 20 May 2019
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3D Structures of cryptochrome
Updated on 20-May-2019
4i6e, 4k0r, 5t5x – mCry-1 – mouse
4jzy, 4gu5, 4k03 – Cry-1 + FAD – Drosophila melanogaster
1u3c – AtCry-1 PHR domain + FAD - Arabidopsis thaliana
1u3d – AtCry-1 PHR domain + FAD + AMPPNP
4ct0 – mCry-1 + PER2
4i6g – mCry-2 + FAD
4i6j – mCry-2 + F-box/LRR repeat protein + S-phase kinase-associated protein
4u8h – mCry-2 + PER2
4mlp – mCry-2 + carbazol derivative
3zxs – Cry-2 + FAD – Rhodobacter sphaeroides
2j4d, 2ijg – AtCry-3 + FAD
2vtb – AtCry-3 + FAD + DNA
3fy4 – AtCry 6-4 + FAD
1np7 – Cry - Synechocystis
6fn3, 5zm0 – CrCry + FAD – Chlamydomonas reinhardtii
6fn2 – CrCry + FAD + alloxazine derivative
6fn0 – CrCry + FAD + DNA + pyrimidine derivative
References
- ↑ Yoshii T, Todo T, Wulbeck C, Stanewsky R, Helfrich-Forster C. Cryptochrome is present in the compound eyes and a subset of Drosophila's clock neurons. J Comp Neurol. 2008 Jun 20;508(6):952-66. doi: 10.1002/cne.21702. PMID:18399544 doi:http://dx.doi.org/10.1002/cne.21702
- ↑ Narasimamurthy R, Hatori M, Nayak SK, Liu F, Panda S, Verma IM. Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12662-7. doi:, 10.1073/pnas.1209965109. Epub 2012 Jul 9. PMID:22778400 doi:http://dx.doi.org/10.1073/pnas.1209965109
