2ga7
From Proteopedia
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'''Solution structure of the copper(I) form of the third metal-binding domain of ATP7A protein (menkes disease protein)''' | '''Solution structure of the copper(I) form of the third metal-binding domain of ATP7A protein (menkes disease protein)''' | ||
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[[Category: SPINE, Structural Proteomics in Europe.]] | [[Category: SPINE, Structural Proteomics in Europe.]] | ||
[[Category: Wuthrich, K.]] | [[Category: Wuthrich, K.]] | ||
| - | [[Category: | + | [[Category: Menkes disease-associated protein]] |
| - | + | [[Category: Nmr]] | |
| - | [[Category: | + | [[Category: Solution structure]] |
| - | [[Category: | + | [[Category: Spine]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Structural proteomics in europe]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:19:33 2008'' |
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Revision as of 05:19, 13 April 2008
Solution structure of the copper(I) form of the third metal-binding domain of ATP7A protein (menkes disease protein)
Overview
The third metal-binding domain of the human Menkes protein (MNK3), a copper(I)-transporting ATPase, has been expressed in Escherichia coli and characterized in solution. The solution structure of MNK3, its copper(I)-binding properties, and its interaction with the physiological partner, HAH1, have been studied. MNK3 is the domain most dissimilar in structure from the other domains of the Menkes protein. This is reflected in a significant rearrangement of the last strand of the four-stranded beta-sheet when compared with the other known homologous proteins or protein domains. MNK3 is also peculiar with respect to its interaction with the copper(I) ion, as it was found to be a comparatively weak binder. Copper(I) transfer from metal-loaded HAH1 was observed experimentally, but the metal distribution was shifted toward binding by HAH1. This is at variance with what is observed for the other Menkes domains.
About this Structure
2GA7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure and intermolecular interactions of the third metal-binding domain of ATP7A, the Menkes disease protein., Banci L, Bertini I, Cantini F, DellaMalva N, Herrmann T, Rosato A, Wuthrich K, J Biol Chem. 2006 Sep 29;281(39):29141-7. Epub 2006 Jul 26. PMID:16873374 Page seeded by OCA on Sun Apr 13 08:19:33 2008
Categories: Copper-exporting ATPase | Homo sapiens | Single protein | Banci, L. | Bertini, I. | Cantini, F. | DellaMalva, N. | Herrmann, T. | Rosato, A. | SPINE, Structural Proteomics in Europe. | Wuthrich, K. | Menkes disease-associated protein | Nmr | Solution structure | Spine | Structural genomic | Structural proteomics in europe
