2ggp

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[[Image:2ggp.gif|left|200px]]
[[Image:2ggp.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ggp |SIZE=350|CAPTION= <scene name='initialview01'>2ggp</scene>
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The line below this paragraph, containing "STRUCTURE_2ggp", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Copper-exporting_ATPase Copper-exporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.4 3.6.3.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ATX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), CCC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_2ggp| PDB=2ggp | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ggp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ggp OCA], [http://www.ebi.ac.uk/pdbsum/2ggp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ggp RCSB]</span>
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}}
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'''Solution structure of the Atx1-Cu(I)-Ccc2a complex'''
'''Solution structure of the Atx1-Cu(I)-Ccc2a complex'''
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[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: SPINE, Structural Proteomics in Europe.]]
[[Category: Voulgaris, P.]]
[[Category: Voulgaris, P.]]
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[[Category: Complex]]
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[[Category: copper transport]]
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[[Category: Copper transport]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:19:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:16:26 2008''
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Revision as of 05:19, 13 April 2008

Image:2ggp.gif

Template:STRUCTURE 2ggp

Solution structure of the Atx1-Cu(I)-Ccc2a complex


Overview

Cellular systems allow transition-metal ions to reach or leave the cell or intracellular locations through metal transfer between proteins. By coupling mutagenesis and advanced NMR experiments, we structurally characterized the adduct between the copper chaperone Atx1 and the first copper(I)-binding domain of the Ccc2 ATPase. Copper was required for the interaction. This study provides an understanding of metal-mediated protein-protein interactions in which the metal ion is essential for the weak, reversible interaction between the partners.

About this Structure

2GGP is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction., Banci L, Bertini I, Cantini F, Felli IC, Gonnelli L, Hadjiliadis N, Pierattelli R, Rosato A, Voulgaris P, Nat Chem Biol. 2006 Jul;2(7):367-8. Epub 2006 May 28. PMID:16732294 Page seeded by OCA on Sun Apr 13 08:19:43 2008

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