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6ilk

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'''Unreleased structure'''
 
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The entry 6ilk is ON HOLD until Paper Publication
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==Cryo-EM structure of Echovirus 6 complexed with its attachment receptor CD55 at PH 7.4==
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<StructureSection load='6ilk' size='340' side='right'caption='[[6ilk]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ilk]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Echovirus_e6 Echovirus e6] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ILK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ILK FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD55 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ilk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ilk OCA], [http://pdbe.org/6ilk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ilk RCSB], [http://www.ebi.ac.uk/pdbsum/6ilk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ilk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN]] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Echovirus e6]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Gao, G F]]
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[[Category: Liu, S]]
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[[Category: Peng, R]]
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[[Category: Zhao, X]]
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[[Category: Cd55]]
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[[Category: Cryo-em]]
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[[Category: Echovirus 6]]
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[[Category: Virus]]
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[[Category: Virus-receptor complex]]

Revision as of 07:27, 21 May 2019

Cryo-EM structure of Echovirus 6 complexed with its attachment receptor CD55 at PH 7.4

PDB ID 6ilk

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