6jo8

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m (Protected "6jo8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6jo8 is ON HOLD
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==The complex structure of CHIKV envelope glycoprotein bound to human MXRA8==
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<StructureSection load='6jo8' size='340' side='right'caption='[[6jo8]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors: Song, H., Zhao, Z., Qi, J., Gao, F., Gao, F.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6jo8]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Chikv Chikv] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JO8 FirstGlance]. <br>
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Description: The complex structure of CHIKV envelope glycoprotein bound to human MXRA8
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MXRA8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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[[Category: Gao, F.G]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Togavirin Togavirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.90 3.4.21.90] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jo8 OCA], [http://pdbe.org/6jo8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jo8 RCSB], [http://www.ebi.ac.uk/pdbsum/6jo8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jo8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MXRA8_HUMAN MXRA8_HUMAN]] Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity).[UniProtKB:Q9DBV4]<ref>PMID:22492581</ref> <ref>PMID:23386276</ref> (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses.<ref>PMID:29769725</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chikv]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Togavirin]]
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[[Category: Gao, F]]
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[[Category: Gao, F G]]
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[[Category: Qi, J]]
[[Category: Song, H]]
[[Category: Song, H]]
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[[Category: Gao, F]]
 
[[Category: Zhao, Z]]
[[Category: Zhao, Z]]
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[[Category: Qi, J]]
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[[Category: Arthritogenic alphaviruse]]
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[[Category: Chikungunya virus]]
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[[Category: Mxra8]]
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[[Category: Receptor]]
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[[Category: Viral protein]]

Revision as of 07:31, 21 May 2019

The complex structure of CHIKV envelope glycoprotein bound to human MXRA8

PDB ID 6jo8

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