5mlp
From Proteopedia
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==Structure of CDPS from Rickettsiella grylli== | ==Structure of CDPS from Rickettsiella grylli== | ||
| - | <StructureSection load='5mlp' size='340' side='right' caption='[[5mlp]], [[Resolution|resolution]] 1.99Å' scene=''> | + | <StructureSection load='5mlp' size='340' side='right'caption='[[5mlp]], [[Resolution|resolution]] 1.99Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5mlp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MLP FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5mlp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"rickettsiella_grylli"_vago_and_martoja_1963 "rickettsiella grylli" vago and martoja 1963]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MLP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MLP FirstGlance]. <br> |
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q24|4q24]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q24|4q24]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RICGR_1344 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=59196 "Rickettsiella grylli" Vago and Martoja 1963])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlp OCA], [http://pdbe.org/5mlp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mlp RCSB], [http://www.ebi.ac.uk/pdbsum/5mlp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlp OCA], [http://pdbe.org/5mlp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mlp RCSB], [http://www.ebi.ac.uk/pdbsum/5mlp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cyclodipeptide synthases (CDPSs) use two aminoacyl-tRNAs to catalyze the formation of two peptide bonds leading to cyclodipeptides that can be further used for the synthesis of diketopiperazines. It was shown that CDPSs fall into two subfamilies, NYH and XYP, characterized by the presence of specific sequence signatures. However, current understanding of CDPSs only comes from studies of enzymes from the NYH subfamily. The present study reveals the crystal structures of three CDPSs from the XYP subfamily. Comparison of the XYP and NYH enzymes shows that the two subfamilies mainly differ in the first half of their Rossmann fold. This gives a structural basis for the partition of CDPSs into two subfamilies. Despite these differences, the catalytic residues adopt similar positioning regardless of the subfamily suggesting that the XYP and NYH motifs correspond to two structural solutions to facilitate the reactivity of the catalytic serine residue. | ||
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| + | Structural basis for partition of the cyclodipeptide synthases into two subfamilies.,Bourgeois G, Seguin J, Babin M, Belin P, Moutiez M, Mechulam Y, Gondry M, Schmitt E J Struct Biol. 2018 Jul;203(1):17-26. doi: 10.1016/j.jsb.2018.03.001. Epub 2018, Mar 2. PMID:29505829<ref>PMID:29505829</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5mlp" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Rickettsiella grylli vago and martoja 1963]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Babin, M]] | [[Category: Babin, M]] | ||
[[Category: Belin, P]] | [[Category: Belin, P]] | ||
Revision as of 08:04, 21 May 2019
Structure of CDPS from Rickettsiella grylli
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