5v68
From Proteopedia
(Difference between revisions)
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==Crystal structure of cell division protein FtsZ from Mycobacterium tuberculosis bounded via the T9 loop== | ==Crystal structure of cell division protein FtsZ from Mycobacterium tuberculosis bounded via the T9 loop== | ||
| - | <StructureSection load='5v68' size='340' side='right' caption='[[5v68]], [[Resolution|resolution]] 3.46Å' scene=''> | + | <StructureSection load='5v68' size='340' side='right'caption='[[5v68]], [[Resolution|resolution]] 3.46Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5v68]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V68 FirstGlance]. <br> | <table><tr><td colspan='2'>[[5v68]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycta Mycta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V68 FirstGlance]. <br> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FTSZ_MYCTA FTSZ_MYCTA]] Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells (By similarity). Binds GTP and shows GTPase activity.[HAMAP-Rule:MF_00909]<ref>PMID:17068335</ref> | [[http://www.uniprot.org/uniprot/FTSZ_MYCTA FTSZ_MYCTA]] Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells (By similarity). Binds GTP and shows GTPase activity.[HAMAP-Rule:MF_00909]<ref>PMID:17068335</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | As of 2017, tuberculosis had infected 1.7 billion people (23% of the population of the world) and caused ten million deaths. Mycobacterium tuberculosis (Mtb) is quickly evolving, and new strains are classified as multidrug resistant. Thus, the identification of novel druggable targets is essential to combat the proliferation of these drug-resistant strains. Filamenting temperature-sensitive mutant Z (FtsZ) is a key protein involved in cytokinesis, an important process for Mtb proliferation and viability. FtsZ is required for bacterial cell division because it polymerizes into a structure called the Z-ring, which recruits accessory division proteins to the septum. Here, the crystal structure of the MtbFtsZ protein has been determined to 3.46 A resolution and is described as a dimer of trimers, with an inter-subunit interface between protomers AB and DE. In this work, a novel conformation of MtbFtsZ is revealed involving the T9 loop and the nucleotide-binding pocket of protomers BC and EF. | ||
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| + | Novel T9 loop conformation of filamenting temperature-sensitive mutant Z from Mycobacterium tuberculosis.,Lazo EO, Jakoncic J, RoyChowdhury S, Awasthi D, Ojima I Acta Crystallogr F Struct Biol Commun. 2019 May 1;75(Pt 5):359-367. doi:, 10.1107/S2053230X19004618. Epub 2019 Apr 24. PMID:31045565<ref>PMID:31045565</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5v68" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Cell division protein 3D structures|Cell division protein 3D structures]] | ||
| + | *[[Journal:Acta Cryst F:S2053230X19004618|Journal:Acta Cryst F:S2053230X19004618]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mycta]] | [[Category: Mycta]] | ||
[[Category: Awasthi, D]] | [[Category: Awasthi, D]] | ||
Revision as of 08:06, 21 May 2019
Crystal structure of cell division protein FtsZ from Mycobacterium tuberculosis bounded via the T9 loop
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Categories: Large Structures | Mycta | Awasthi, D | Chowdhury, S R | Jakoncic, J | Lazo, E O | Ojima, I | Cell cycle | Gdp | Mtbftsz | Phosphate | T9 loop | Z-ring
