6e0c

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'''Unreleased structure'''
 
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The entry 6e0c is ON HOLD until Paper Publication
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==Cryo-EM structure of the CENP-A nucleosome (W601) in complex with a single chain antibody fragment==
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<StructureSection load='6e0c' size='340' side='right'caption='[[6e0c]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6e0c]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E0C FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e0c OCA], [http://pdbe.org/6e0c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e0c RCSB], [http://www.ebi.ac.uk/pdbsum/6e0c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e0c ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> [[http://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Yadav, K N.S]]
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[[Category: Zhou, B R]]
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[[Category: Acidic patch]]
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[[Category: Anti-nucleosome antibody]]
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[[Category: Cenp-a]]
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[[Category: Centromere]]
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[[Category: Nuclear protein]]
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[[Category: Widom's 601 dna]]

Revision as of 06:44, 23 May 2019

Cryo-EM structure of the CENP-A nucleosome (W601) in complex with a single chain antibody fragment

PDB ID 6e0c

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