6nk7

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'''Unreleased structure'''
 
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The entry 6nk7 is ON HOLD until Paper Publication
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==Electron Cryo-Microscopy of Chikungunya in Complex with Mouse Mxra8 Receptor==
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<StructureSection load='6nk7' size='340' side='right'caption='[[6nk7]], [[Resolution|resolution]] 4.99&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6nk7]] is a 17 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NK7 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Togavirin Togavirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.90 3.4.21.90] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nk7 OCA], [http://pdbe.org/6nk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nk7 RCSB], [http://www.ebi.ac.uk/pdbsum/6nk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nk7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MXRA8_MOUSE MXRA8_MOUSE]] Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461).[UniProtKB:Q9BRK3]<ref>PMID:14603461</ref> <ref>PMID:18366072</ref> <ref>PMID:22492581</ref> <ref>PMID:29702220</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Togavirin]]
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[[Category: Basore, K]]
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[[Category: Structural genomic]]
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[[Category: Fremont, D H]]
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[[Category: Kim, A S]]
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[[Category: Nelson, C A]]
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[[Category: Chikungunya]]
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[[Category: Csgid]]
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[[Category: Mxra8]]
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[[Category: Viral receptor]]
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[[Category: Virus]]

Revision as of 06:53, 23 May 2019

Electron Cryo-Microscopy of Chikungunya in Complex with Mouse Mxra8 Receptor

PDB ID 6nk7

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OCA

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