6o7g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of MLL4 PHD6 domain in complex with histone H4K16ac peptide== | |
| - | + | <StructureSection load='6o7g' size='340' side='right'caption='[[6o7g]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6o7g]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O7G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o7g OCA], [http://pdbe.org/6o7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o7g RCSB], [http://www.ebi.ac.uk/pdbsum/6o7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o7g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN]] Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.<ref>PMID:16603732</ref> <ref>PMID:17500065</ref> <ref>PMID:17851529</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Histone-lysine N-methyltransferase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kutateladze, T G]] | ||
| + | [[Category: Zhang, Y]] | ||
| + | [[Category: Acetylation]] | ||
| + | [[Category: Chromatin]] | ||
| + | [[Category: H4k16ac]] | ||
| + | [[Category: Histone]] | ||
| + | [[Category: Mll4]] | ||
| + | [[Category: Mof]] | ||
| + | [[Category: Phd finger]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 06:55, 23 May 2019
Solution structure of MLL4 PHD6 domain in complex with histone H4K16ac peptide
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