6okk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit== | |
| - | + | <StructureSection load='6okk' size='340' side='right'caption='[[6okk]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6okk]] is a 33 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_(isolate_3d7) Plasmodium falciparum (isolate 3d7)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OKK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6okk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6okk OCA], [http://pdbe.org/6okk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6okk RCSB], [http://www.ebi.ac.uk/pdbsum/6okk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6okk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RSSA_PLAF7 RSSA_PLAF7]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Scheres, S H.W]] | ||
[[Category: Wong, W]] | [[Category: Wong, W]] | ||
| - | [[Category: | + | [[Category: Antimalarial drug]] |
| + | [[Category: Protein synthesis]] | ||
| + | [[Category: Ribosome]] | ||
| + | [[Category: Ribosome-inhibitor complex]] | ||
Revision as of 06:56, 23 May 2019
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit
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