6bi6
From Proteopedia
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==Solution NMR structure of uncharacterized protein YejG== | ==Solution NMR structure of uncharacterized protein YejG== | ||
| - | <StructureSection load='6bi6' size='340' side='right' caption='[[6bi6]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | + | <StructureSection load='6bi6' size='340' side='right'caption='[[6bi6]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6bi6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BI6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6bi6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BI6 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bi6 OCA], [http://pdbe.org/6bi6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bi6 RCSB], [http://www.ebi.ac.uk/pdbsum/6bi6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bi6 ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yejG, b2181, JW2169 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bi6 OCA], [http://pdbe.org/6bi6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bi6 RCSB], [http://www.ebi.ac.uk/pdbsum/6bi6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bi6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | InterPro family IPR020489 comprises ~1000 uncharacterized bacterial proteins. Previously we showed that overexpressing the Escherichia coli representative of this family, EcYejG, conferred low-level resistance to aminoglycoside antibiotics. In an attempt to shed light on the biochemical function of EcYejG, we have solved its structure using multinuclear solution NMR spectroscopy. The structure most closely resembles that of domain III from elongation factor G (EF-G). EF-G catalyzes ribosomal translocation and mutations in EF-G have also been associated with aminoglycoside resistance. While we were unable to demonstrate a direct interaction between EcYejG and the ribosome, the protein might play a role in translation. | ||
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| + | The uncharacterized bacterial protein YejG has the same architecture as domain III of elongation factor G.,Mohanty B, Hanson-Manful P, Finn TJ, Chambers CR, McKellar JLO, Macindoe I, Helder S, Setiyaputra S, Zhong Y, Mackay JP, Patrick WM Proteins. 2019 Apr 8. doi: 10.1002/prot.25687. PMID:30958578<ref>PMID:30958578</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6bi6" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Ecoli]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Finn, T J]] | [[Category: Finn, T J]] | ||
[[Category: Macindoe, I]] | [[Category: Macindoe, I]] | ||
Revision as of 07:27, 23 May 2019
Solution NMR structure of uncharacterized protein YejG
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Categories: Ecoli | Large Structures | Finn, T J | Macindoe, I | Mackay, J P | Mohanty, B | Patrick, W M | Zhong, J | Pf13989 | Unknown function | Yejg
