6gqe
From Proteopedia
(Difference between revisions)
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<StructureSection load='6gqe' size='340' side='right'caption='[[6gqe]], [[Resolution|resolution]] 2.15Å' scene=''> | <StructureSection load='6gqe' size='340' side='right'caption='[[6gqe]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6gqe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GQE FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6gqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GQE FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gqe OCA], [http://pdbe.org/6gqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gqe RCSB], [http://www.ebi.ac.uk/pdbsum/6gqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gqe ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGF2BP3, IMP3, KOC1, VICKZ3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gqe OCA], [http://pdbe.org/6gqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gqe RCSB], [http://www.ebi.ac.uk/pdbsum/6gqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gqe ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IF2B3_HUMAN IF2B3_HUMAN]] RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.<ref>PMID:16541107</ref> <ref>PMID:23640942</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Pig]] | ||
[[Category: Janowski, R]] | [[Category: Janowski, R]] | ||
[[Category: Niessing, D]] | [[Category: Niessing, D]] | ||
Revision as of 07:30, 23 May 2019
X-ray structure of KH1-2 domain of IMP3
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