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4wrs
From Proteopedia
(Difference between revisions)
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==Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor.== | ==Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor.== | ||
| - | <StructureSection load='4wrs' size='340' side='right' caption='[[4wrs]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='4wrs' size='340' side='right'caption='[[4wrs]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4wrs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WRS FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4wrs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WRS FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3U1:3-{6-[(4R)-6-AZASPIRO[2.5]OCT-4-YLOXY]PYRAZIN-2-YL}-5-(2,6-DIFLUOROPHENYL)-1H-INDAZOLE'>3U1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3U1:3-{6-[(4R)-6-AZASPIRO[2.5]OCT-4-YLOXY]PYRAZIN-2-YL}-5-(2,6-DIFLUOROPHENYL)-1H-INDAZOLE'>3U1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wrs OCA], [http://pdbe.org/4wrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wrs RCSB], [http://www.ebi.ac.uk/pdbsum/4wrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wrs ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wrs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wrs OCA], [http://pdbe.org/4wrs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wrs RCSB], [http://www.ebi.ac.uk/pdbsum/4wrs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wrs ProSAT]</span></td></tr> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4wrs" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4wrs" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Proto-oncogene serine/threonine-protein kinase|Proto-oncogene serine/threonine-protein kinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Mohr, C]] | [[Category: Mohr, C]] | ||
[[Category: Serine/threonine protein kinase]] | [[Category: Serine/threonine protein kinase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 07:51, 23 May 2019
Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor.
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