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4v46
From Proteopedia
(Difference between revisions)
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==Crystal structure of the BAFF-BAFF-R complex== | ==Crystal structure of the BAFF-BAFF-R complex== | ||
| - | <StructureSection load='4v46' size='340' side='right' caption='[[4v46]], [[Resolution|resolution]] 3.30Å' scene=''> | + | <StructureSection load='4v46' size='340' side='right'caption='[[4v46]], [[Resolution|resolution]] 3.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4v46]] is a 120 chain structure. This structure supersedes | + | <table><tr><td colspan='2'>[[4v46]] is a 120 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1otz 1otz] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1p0t 1p0t]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V46 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V46 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v46 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v46 RCSB], [http://www.ebi.ac.uk/pdbsum/4v46 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v46 OCA], [http://pdbe.org/4v46 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v46 RCSB], [http://www.ebi.ac.uk/pdbsum/4v46 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4v46 ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | {{Large structure}} | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[http://omim.org/entry/613494 613494]]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref> | [[http://www.uniprot.org/uniprot/TR13C_HUMAN TR13C_HUMAN]] Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:[http://omim.org/entry/613494 613494]]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:19666484</ref> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4v46" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Kim, H M]] | [[Category: Kim, H M]] | ||
[[Category: Kim, Y S]] | [[Category: Kim, Y S]] | ||
Revision as of 08:59, 23 May 2019
Crystal structure of the BAFF-BAFF-R complex
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