This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4wh8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal Structure of HCV NS3/4A protease in complex with an Asunaprevir P1-P3 macrocyclic analog.== | ==Crystal Structure of HCV NS3/4A protease in complex with an Asunaprevir P1-P3 macrocyclic analog.== | ||
| - | <StructureSection load='4wh8' size='340' side='right' caption='[[4wh8]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='4wh8' size='340' side='right'caption='[[4wh8]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4wh8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WH8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4wh8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WH8 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3M7:TERT-BUTYL+[(2R,6S,12Z,13AS,14AR,16AS)-2-[(7-CHLORO-4-METHOXYISOQUINOLIN-1-YL)OXY]-14A-{[CYCLOPROPYL(DIHYDROXY)-LAMBDA~4~-SULFANYL]CARBAMOYL}-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13A,14,14A,15,16,16A-HEXADECAHYDROCYCLOPROPA[E]PYRROLO[1,2-A][1,4]DIAZACYCLOPENTADECIN-6-YL]CARBAMATE'>3M7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3M7:TERT-BUTYL+[(2R,6S,12Z,13AS,14AR,16AS)-2-[(7-CHLORO-4-METHOXYISOQUINOLIN-1-YL)OXY]-14A-{[CYCLOPROPYL(DIHYDROXY)-LAMBDA~4~-SULFANYL]CARBAMOYL}-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13A,14,14A,15,16,16A-HEXADECAHYDROCYCLOPROPA[E]PYRROLO[1,2-A][1,4]DIAZACYCLOPENTADECIN-6-YL]CARBAMATE'>3M7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wh6|4wh6]], [[4wf8|4wf8]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wh6|4wh6]], [[4wf8|4wf8]]</td></tr> | ||
| Line 21: | Line 21: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Hepatitis c virus subtype 1a]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Ali, A]] | [[Category: Ali, A]] | ||
[[Category: Schiffer, C A]] | [[Category: Schiffer, C A]] | ||
| Line 26: | Line 28: | ||
[[Category: Asunaprevir]] | [[Category: Asunaprevir]] | ||
[[Category: Hcv drug resistance]] | [[Category: Hcv drug resistance]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Macrocycle]] | [[Category: Macrocycle]] | ||
[[Category: Protease-inhibitor complex]] | [[Category: Protease-inhibitor complex]] | ||
Revision as of 09:03, 23 May 2019
Crystal Structure of HCV NS3/4A protease in complex with an Asunaprevir P1-P3 macrocyclic analog.
| |||||||||||
