Cytochrome c oxidase
From Proteopedia
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Mammalian CcO is composed of <scene name='46/466466/Cv/9'>13 subunits</scene>, <scene name='46/466466/Cv/10'>2 hemes, two copper centers</scene>, and cytochrome a and a3. The fully oxidized form of <scene name='46/466466/Cv/11'>CcO active site shows the heme, Cu+2 ion and an O2</scene> molecule. <scene name='46/466466/Cv/12'>Second heme binding site</scene>. <ref>PMID:9624044</ref> Bacterial CcO is composed of 2 subunits. | Mammalian CcO is composed of <scene name='46/466466/Cv/9'>13 subunits</scene>, <scene name='46/466466/Cv/10'>2 hemes, two copper centers</scene>, and cytochrome a and a3. The fully oxidized form of <scene name='46/466466/Cv/11'>CcO active site shows the heme, Cu+2 ion and an O2</scene> molecule. <scene name='46/466466/Cv/12'>Second heme binding site</scene>. <ref>PMID:9624044</ref> Bacterial CcO is composed of 2 subunits. | ||
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| + | == 3D Structures of Cytochrome c oxidase == | ||
| + | [[Cytochrome c oxidase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
== 3D Structures of Cytochrome c oxidase == | == 3D Structures of Cytochrome c oxidase == | ||
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*Mammalian CcO | *Mammalian CcO | ||
| - | **[[1occ]], [[2occ]], [[1v54]], [[2dyr]], [[2zxw]], [[3abl]], [[3abm]], [[3asn]], [[3aso]], [[3x2q]] – bCcO oxidized – bovine<br /> | + | **[[5z62]] - CcO – human – Cryo EM<br /> |
| + | **[[1occ]], [[2occ]], [[1v54]], [[2dyr]], [[2zxw]], [[3abl]], [[3abm]], [[3asn]], [[3aso]], [[3x2q]], [[6nmp]] – bCcO oxidized – bovine<br /> | ||
**[[2eil]], [[2ein]], [[5b1a]], [[5xdq]] - bCcO oxidized + meta<br /> | **[[2eil]], [[2ein]], [[5b1a]], [[5xdq]] - bCcO oxidized + meta<br /> | ||
**[[1ocr]], [[1v55]], [[2eij]], [[3ag1]] – bCcO reduced<br /> | **[[1ocr]], [[1v55]], [[2eij]], [[3ag1]] – bCcO reduced<br /> | ||
| - | **[[2eik]], [[2eim]], [[5b1b]], [[5xdx]] - bCcO reduced + metal<br /> | + | **[[2eik]], [[2eim]], [[5b1b]], [[5xdx]], [[6nmf]] - bCcO reduced + metal<br /> |
**[[3abk]], [[3ag3]] - bCcO reduced + NO<br /> | **[[3abk]], [[3ag3]] - bCcO reduced + NO<br /> | ||
**[[3ag2]] - bCcO reduced + CO<br /> | **[[3ag2]] - bCcO reduced + CO<br /> | ||
**[[3ag4]] - bCcO reduced + CN<br /> | **[[3ag4]] - bCcO reduced + CN<br /> | ||
| - | **[[1ocz]] – bCcO + N3<br /> | + | **[[1ocz]], [[5zcq]], [[5zcp]], [[5zco]], [[5z86]], [[5z85]], [[5z84]] – bCcO + N3<br /> |
**[[2y69]], [[3wg7]] – bCcO + O2<br /> | **[[2y69]], [[3wg7]] – bCcO + O2<br /> | ||
| + | **[[6nkn]] - bCcO + O<br /> | ||
**[[1oco]], [[5b3s]], [[5x1f]], [[5x1b]], [[5x19]], [[5wau]], [[5w97]] - bCcO + CO<br /> | **[[1oco]], [[5b3s]], [[5x1f]], [[5x1b]], [[5x19]], [[5wau]], [[5w97]] - bCcO + CO<br /> | ||
**[[2dys]] – bCcO + lipids<br /> | **[[2dys]] – bCcO + lipids<br /> | ||
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**[[2ybb]] – bCcO + cytochrome bc1 complex + NADH-quinone oxidoreductase – Cryo EM<br /> | **[[2ybb]] – bCcO + cytochrome bc1 complex + NADH-quinone oxidoreductase – Cryo EM<br /> | ||
**[[5iy5]] – bCcO + cytochrome c<br /> | **[[5iy5]] – bCcO + cytochrome c<br /> | ||
| + | **[[6hu9]], [[6giq]] – CcO + cytochrome c + cytochrome b-c1 + cytochrome b + cytochrome c1 - yeast<br /> | ||
*Bacterial CcO | *Bacterial CcO | ||
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**[[2gsm]] – RsCcO subunit I+II<br /> | **[[2gsm]] – RsCcO subunit I+II<br /> | ||
**[[3fye]] - RsCcO subunit I+II reduced<br /> | **[[3fye]] - RsCcO subunit I+II reduced<br /> | ||
| - | **[[3om3]], [[3oma]], [[3omi]], [[3omn]] - RsCcO subunit I+II reduced (mutant) <br /> | + | **[[3om3]], [[3oma]], [[3omi]], [[3omn]], [[6cio]] - RsCcO subunit I+II reduced (mutant) <br /> |
**[[3fyi]] - RsCcO subunit I+II reduced + CN<br /> | **[[3fyi]] - RsCcO subunit I+II reduced + CN<br /> | ||
**[[3dtu]] - RsCcO subunit I+II + deoxycholic acid<br /> | **[[3dtu]] - RsCcO subunit I+II + deoxycholic acid<br /> | ||
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**[[4txv]] - CcO subunit II + TlpA – ''Bradyrhizobium diazoefficiens''<br /> | **[[4txv]] - CcO subunit II + TlpA – ''Bradyrhizobium diazoefficiens''<br /> | ||
**[[4w9z]] - CcO subunit II – ''Bradyhisobium diazoefficiens''<br /> | **[[4w9z]] - CcO subunit II – ''Bradyhisobium diazoefficiens''<br /> | ||
| + | **[[6hwh]], [[6adq]] - CcO subunit I+II+III + ubiquinol cytochrome c reductase – ''Mycobacterium smegmatis'' – Cryo EM<br /> | ||
*Ba3-type CcO | *Ba3-type CcO | ||
Revision as of 08:57, 27 May 2019
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3D Structures of Cytochrome c oxidase
Updated on 27-May-2019
References
- ↑ Tsukihara T, Aoyama H, Yamashita E, Tomizaki T, Yamaguchi H, Shinzawa-Itoh K, Nakashima R, Yaono R, Yoshikawa S. Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A. Science. 1995 Aug 25;269(5227):1069-74. PMID:7652554
- ↑ Yoshikawa S, Shinzawa-Itoh K, Nakashima R, Yaono R, Yamashita E, Inoue N, Yao M, Fei MJ, Libeu CP, Mizushima T, Yamaguchi H, Tomizaki T, Tsukihara T. Redox-coupled crystal structural changes in bovine heart cytochrome c oxidase. Science. 1998 Jun 12;280(5370):1723-9. PMID:9624044
