6hl0

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m (Protected "6hl0" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6hl0 is ON HOLD until Paper Publication
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==Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide==
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<StructureSection load='6hl0' size='340' side='right'caption='[[6hl0]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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Authors: Kudlinzki, D., Merk, D., Linhard, V.L., Saxena, K., Schubert-Zsilavecz, M., Schwalbe, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6hl0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HL0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HL0 FirstGlance]. <br>
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Description: Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hl0 OCA], [http://pdbe.org/6hl0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hl0 RCSB], [http://www.ebi.ac.uk/pdbsum/6hl0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hl0 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Linhard, V.L]]
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== Function ==
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[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Kudlinzki, D]]
[[Category: Kudlinzki, D]]
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[[Category: Linhard, V L]]
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[[Category: Merk, D]]
[[Category: Saxena, K]]
[[Category: Saxena, K]]
[[Category: Schubert-Zsilavecz, M]]
[[Category: Schubert-Zsilavecz, M]]
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[[Category: Merk, D]]
 
[[Category: Schwalbe, H]]
[[Category: Schwalbe, H]]
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[[Category: Activator]]
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[[Category: Complex]]
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[[Category: Dna-binding]]
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[[Category: Nuclear protein]]
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[[Category: Receptor]]
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[[Category: Repressor]]

Revision as of 06:08, 29 May 2019

Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide

PDB ID 6hl0

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