6mju

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'''Unreleased structure'''
 
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The entry 6mju is ON HOLD until Paper Publication
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==human cGAS catalytic domain bound with the inhibitor G108==
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<StructureSection load='6mju' size='340' side='right'caption='[[6mju]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6mju]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJU FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JUM:1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one'>JUM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mju OCA], [http://pdbe.org/6mju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mju RCSB], [http://www.ebi.ac.uk/pdbsum/6mju PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mju ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cyclic GMP-AMP synthase]]
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[[Category: Large Structures]]
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[[Category: Adura, C]]
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[[Category: Aida, J]]
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[[Category: Asano, Y]]
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[[Category: Gao, P]]
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[[Category: Glickman, J F]]
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[[Category: Gogakos, T]]
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[[Category: Hashizume, S]]
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[[Category: Imaeda, T]]
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[[Category: Jennings, A J]]
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[[Category: Kamei, T]]
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[[Category: Kuroita, T]]
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[[Category: Kuryavyi, V]]
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[[Category: Lama, L]]
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[[Category: Meinke, P]]
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[[Category: Michinom, M]]
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[[Category: Miller, M]]
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[[Category: Okamoto, R]]
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[[Category: Patel, D J]]
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[[Category: Ramos-Espiritu, L]]
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[[Category: Stamford, A]]
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[[Category: Steinberg, J I]]
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[[Category: Tomita, D]]
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[[Category: Tuschl, T]]
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[[Category: Xie, W]]
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[[Category: Dna sensor]]
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[[Category: Human cga]]
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[[Category: Immune system]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 06:13, 29 May 2019

human cGAS catalytic domain bound with the inhibitor G108

PDB ID 6mju

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OCA

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