6mjx
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==human cGAS catalytic domain bound with cGAMP== | |
| - | + | <StructureSection load='6mjx' size='340' side='right'caption='[[6mjx]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mjx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjx OCA], [http://pdbe.org/6mjx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjx RCSB], [http://www.ebi.ac.uk/pdbsum/6mjx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cyclic GMP-AMP synthase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Adura, C]] | ||
| + | [[Category: Aida, J]] | ||
| + | [[Category: Asano, Y]] | ||
| + | [[Category: Gao, P]] | ||
| + | [[Category: Glickman, J F]] | ||
| + | [[Category: Gogakos, T]] | ||
| + | [[Category: Hashizume, S]] | ||
| + | [[Category: Imaeda, T]] | ||
| + | [[Category: Jennings, A J]] | ||
| + | [[Category: Kamei, T]] | ||
| + | [[Category: Kuroita, T]] | ||
| + | [[Category: Kuryavyi, V]] | ||
| + | [[Category: Lama, L]] | ||
| + | [[Category: Meinke, P]] | ||
| + | [[Category: Michinom, M]] | ||
| + | [[Category: Miller, M]] | ||
| + | [[Category: Okamoto, R]] | ||
| + | [[Category: Patel, D J]] | ||
| + | [[Category: Ramos-Espiritu, L]] | ||
| + | [[Category: Stamford, A]] | ||
| + | [[Category: Steinberg, J I]] | ||
| + | [[Category: Tomita, D]] | ||
| + | [[Category: Tuschl, T]] | ||
| + | [[Category: Xie, W]] | ||
| + | [[Category: Dna sensor]] | ||
| + | [[Category: Human cga]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 06:13, 29 May 2019
human cGAS catalytic domain bound with cGAMP
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Categories: Cyclic GMP-AMP synthase | Large Structures | Adura, C | Aida, J | Asano, Y | Gao, P | Glickman, J F | Gogakos, T | Hashizume, S | Imaeda, T | Jennings, A J | Kamei, T | Kuroita, T | Kuryavyi, V | Lama, L | Meinke, P | Michinom, M | Miller, M | Okamoto, R | Patel, D J | Ramos-Espiritu, L | Stamford, A | Steinberg, J I | Tomita, D | Tuschl, T | Xie, W | Dna sensor | Human cga | Immune system | Transferase-transferase inhibitor complex
