6n3s
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of apo-cruzain== | |
| - | + | <StructureSection load='6n3s' size='340' side='right'caption='[[6n3s]], [[Resolution|resolution]] 1.19Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6n3s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3s OCA], [http://pdbe.org/6n3s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3s RCSB], [http://www.ebi.ac.uk/pdbsum/6n3s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cruzipain]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brandstetter, H]] | ||
| + | [[Category: Dall, E]] | ||
| + | [[Category: Ferreira, R S]] | ||
| + | [[Category: Rodrigues, F T.G]] | ||
| + | [[Category: Silva, E B]] | ||
| + | [[Category: Apo cruzain]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Protease]] | ||
| + | [[Category: Thiol protease]] | ||
Revision as of 06:14, 29 May 2019
Crystal structure of apo-cruzain
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