6o2u
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the SARAF luminal domain== | |
| - | + | <StructureSection load='6o2u' size='340' side='right'caption='[[6o2u]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6o2u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O2U FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o2u OCA], [http://pdbe.org/6o2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o2u RCSB], [http://www.ebi.ac.uk/pdbsum/6o2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o2u ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SARAF_HUMAN SARAF_HUMAN]] Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.<ref>PMID:22464749</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kimberlin, C R]] | ||
| + | [[Category: Minor, D L]] | ||
| + | [[Category: Calcium signaling]] | ||
| + | [[Category: Domain swap]] | ||
| + | [[Category: Endoplasmic reticulum]] | ||
| + | [[Category: Er]] | ||
| + | [[Category: Saraf]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Soce]] | ||
| + | [[Category: Store operated calcium entry]] | ||
Revision as of 06:15, 29 May 2019
Crystal structure of the SARAF luminal domain
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