6o47
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==human cGAS core domain (K427E/K428E) bound with RU-521== | |
| - | + | <StructureSection load='6o47' size='340' side='right'caption='[[6o47]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6o47]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O47 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEV:2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-[(1R)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-1,2-dihydro-3H-pyrazol-3-one'>AEV</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LLS:(3~{S})-3-[1-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-3-methyl-5-oxidanyl-pyrazol-4-yl]-3~{H}-2-benzofuran-1-one'>LLS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o47 OCA], [http://pdbe.org/6o47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o47 RCSB], [http://www.ebi.ac.uk/pdbsum/6o47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o47 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cyclic GMP-AMP synthase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Adura, C]] | ||
| + | [[Category: Glickman, J F]] | ||
| + | [[Category: Lama, L]] | ||
| + | [[Category: Patel, D J]] | ||
| + | [[Category: Tuschl, T]] | ||
| + | [[Category: Xie, W]] | ||
| + | [[Category: Cga]] | ||
| + | [[Category: Compound]] | ||
| + | [[Category: Core domain]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Human]] | ||
| + | [[Category: Ru-521]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 06:16, 29 May 2019
human cGAS core domain (K427E/K428E) bound with RU-521
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Categories: Cyclic GMP-AMP synthase | Large Structures | Adura, C | Glickman, J F | Lama, L | Patel, D J | Tuschl, T | Xie, W | Cga | Compound | Core domain | Dna binding protein | Human | Ru-521 | Transferase
