6o5s
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Room temperature structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B== | |
| - | + | <StructureSection load='6o5s' size='340' side='right'caption='[[6o5s]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6o5s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O5S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LND:4-carbamoyl-1-(3-{2-[(E)-(hydroxyimino)methyl]-1H-imidazol-1-yl}propyl)pyridin-1-ium'>LND</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6o5r|6o5r]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o5s OCA], [http://pdbe.org/6o5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o5s RCSB], [http://www.ebi.ac.uk/pdbsum/6o5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o5s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Acetylcholinesterase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Gerlits, O]] | [[Category: Gerlits, O]] | ||
| + | [[Category: Kovalevsky, A]] | ||
[[Category: Radic, Z]] | [[Category: Radic, Z]] | ||
| - | [[Category: | + | [[Category: Hydrolase]] |
| + | [[Category: Imidazole-based oxime]] | ||
| + | [[Category: Oxime reactivator]] | ||
| + | [[Category: Rs-170b]] | ||
| + | [[Category: Vx-hache]] | ||
| + | [[Category: Vx-phosphonylated]] | ||
Revision as of 06:16, 29 May 2019
Room temperature structure of VX-phosphonylated hAChE in complex with oxime reactivator RS-170B
| |||||||||||
