6ocb
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of FluA-20 Fab in complex with the head domain of H3 (A/Hong Kong/1/1968)== | |
| - | + | <StructureSection load='6ocb' size='340' side='right'caption='[[6ocb]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ocb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OCB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ocb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ocb OCA], [http://pdbe.org/6ocb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ocb RCSB], [http://www.ebi.ac.uk/pdbsum/6ocb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ocb ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lang, S]] | [[Category: Lang, S]] | ||
| + | [[Category: Wilson, I A]] | ||
| + | [[Category: Anti-flu antibody]] | ||
| + | [[Category: Ha head domain]] | ||
| + | [[Category: Immune system]] | ||
Revision as of 06:18, 29 May 2019
Crystal structure of FluA-20 Fab in complex with the head domain of H3 (A/Hong Kong/1/1968)
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