6p0q

Structural highlights

Function

[WDR12_HUMAN] Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.[HAMAP-Rule:MF_03029]^{[1] [2]}

References

1. ↑ Holzel M, Rohrmoser M, Schlee M, Grimm T, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Hiddemann W, Bornkamm GW, Eick D. Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. J Cell Biol. 2005 Aug 1;170(3):367-78. doi: 10.1083/jcb.200501141. Epub 2005 Jul , 25. PMID:16043514 doi:http://dx.doi.org/10.1083/jcb.200501141
2. ↑ Rohrmoser M, Holzel M, Grimm T, Malamoussi A, Harasim T, Orban M, Pfisterer I, Gruber-Eber A, Kremmer E, Eick D. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Mol Cell Biol. 2007 May;27(10):3682-94. Epub 2007 Mar 12. PMID:17353269 doi:http://dx.doi.org/MCB.00172-07