C-X-C motif chemokine
From Proteopedia
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<StructureSection load='1qg7' size='350' side='right' caption='CXCL12α dimer complex with sulfate (PDB code [[1qg7]]).' scene=''> | <StructureSection load='1qg7' size='350' side='right' caption='CXCL12α dimer complex with sulfate (PDB code [[1qg7]]).' scene=''> | ||
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| + | == Function == | ||
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'''C-X-C motif chemokine''' (CXCL) are small chemokines which contain the sequence Cys-X-Cys at their C-terminal. The CXCL are subdivided into 2 groups: ELR positive (containing Glu-Leu-Arg preceding the C-X-C) and ELR negative.<ref>PMID:16212895</ref><br /> | '''C-X-C motif chemokine''' (CXCL) are small chemokines which contain the sequence Cys-X-Cys at their C-terminal. The CXCL are subdivided into 2 groups: ELR positive (containing Glu-Leu-Arg preceding the C-X-C) and ELR negative.<ref>PMID:16212895</ref><br /> | ||
• '''CXCL2''' or '''MIP-2''' or '''imacrophage inflammatory protein 2''' acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.<br /> | • '''CXCL2''' or '''MIP-2''' or '''imacrophage inflammatory protein 2''' acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.<br /> | ||
| - | • '''CXCL10''' or '''IP-10''' or '''interferon γ-induced protein 10''' acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3 | + | • '''CXCL4''' or '''platelet factor 4''' is a pro-inflammatory compound<ref>PMID:27183218</ref><br /> |
| + | • '''CXCL10''' or '''IP-10''' or '''interferon γ-induced protein 10''' acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3<ref>PMID:19105984</ref><br /> | ||
• '''CXCL11''' or '''IP-9''' or '''interferon γ-induced protein 9''' acts as chemotactic for activated T cells.<br /> | • '''CXCL11''' or '''IP-9''' or '''interferon γ-induced protein 9''' acts as chemotactic for activated T cells.<br /> | ||
| - | • '''CXCL12''' or '''Stromal-Derived-Factor-1''' (SDF1) has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis | + | • '''CXCL12''' or '''Stromal-Derived-Factor-1''' (SDF1) has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis<ref>PMID:24024928</ref><br /> |
• '''CXCL14''' or '''BRAK''' acts as chemotactic for monocytes and inhibits angiogenesis.<br /> | • '''CXCL14''' or '''BRAK''' acts as chemotactic for monocytes and inhibits angiogenesis.<br /> | ||
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| + | == Relevance == | ||
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| + | CXCL4 plays an important role in pancreatic inflammation and can be targeted to ameliorate tissue damage in pancreatitis. Levels of CXCL4 are elevated in patients with systemic sclerosis<ref>PMID:24350901</ref>. CXCL12 may be involved in the immune defense pathway during periodontal disease<ref>PMID:18454663</ref>. | ||
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| + | == 3D Structures of C-X-C motif chemokine == | ||
| + | [[C-X-C motif chemokine 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
== 3D Structures of C-X-C motif chemokine == | == 3D Structures of C-X-C motif chemokine == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *CXCL2 | + | *CXCL2 or MIP2 or macrophage inflammatory protein 2 |
| + | **[[5ob5]] – hCXCL + antibody - human<br /> | ||
| + | **[[1qnk]] – hCXCL GROB - NMR<br /> | ||
**[[3n52]] – mCXCL – mouse<br /> | **[[3n52]] – mCXCL – mouse<br /> | ||
**[[1mi2]] – mCXCL – NMR<br /> | **[[1mi2]] – mCXCL – NMR<br /> | ||
| - | **[[ | + | |
| + | * CXCL4 or platelet factor 4 | ||
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| + | **[[1f9q]], [[1rhp]] – hCXCL <br /> | ||
| + | **[[1f9r]], [[1f9s]], [[4hsv]] – hCXCL (mutant)<br /> | ||
| + | **[[4r9w]] – hCXCL + fondaparinux<br /> | ||
| + | **[[4r9y]], [[4rau]] – hCXCL + antibody<br /> | ||
| + | **[[1plf]] – CXCL - bovine<br /> | ||
*CXCL5 | *CXCL5 | ||
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*CXCL8 see interleukin-8 in [[Interleukin]] | *CXCL8 see interleukin-8 in [[Interleukin]] | ||
| - | *CXCL10 | + | *CXCL10 or IP-10 or interferon gamma-induced protein 10 |
**[[1lv9]] – hCXCL – NMR<br /> | **[[1lv9]] – hCXCL – NMR<br /> | ||
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**[[2r3z]] – mCXCL <br /> | **[[2r3z]] – mCXCL <br /> | ||
| - | *CXCL11 | + | *CXCL11 or IP-9 or interferon gamma-induced protein 9 |
**[[1rjt]] – hCXCL<br /> | **[[1rjt]] – hCXCL<br /> | ||
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**[[2nwg]] - hSDF1α+heparin<br /> | **[[2nwg]] - hSDF1α+heparin<br /> | ||
**[[2j7z]] - hSDF1α residues 22-89<br /> | **[[2j7z]] - hSDF1α residues 22-89<br /> | ||
| - | **[[2k03]], [[2k04]], [[2k05]] - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)<br /> | + | **[[2k03]], [[2k04]], [[2k05]], [[2n55]] - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)<br /> |
**[[4lmq]] - hSDF1α + immunoghlobulin heavy chain<br /> | **[[4lmq]] - hSDF1α + immunoghlobulin heavy chain<br /> | ||
| + | **[[4uai]] - hSDF1 inhibitor<br /> | ||
*CXCL13 | *CXCL13 | ||
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**[[5izb]], [[5l7m]] – mCXCL – NMR<br /> | **[[5izb]], [[5l7m]] – mCXCL – NMR<br /> | ||
| - | *CXCL14 | + | *CXCL14 or BRAK |
**[[2hdl]] – hCXCL – NMR<br /> | **[[2hdl]] – hCXCL – NMR<br /> | ||
Revision as of 08:03, 3 June 2019
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3D Structures of C-X-C motif chemokine
Updated on 03-June-2019
References
- ↑ Le Y, Zhou Y, Iribarren P, Wang J. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell Mol Immunol. 2004 Apr;1(2):95-104. PMID:16212895
- ↑ Wetterholm E, Linders J, Merza M, Regner S, Thorlacius H. Platelet-derived CXCL4 regulates neutrophil infiltration and tissue damage in severe acute pancreatitis. Transl Res. 2016 Oct;176:105-18. doi: 10.1016/j.trsl.2016.04.006. Epub 2016 Apr, 29. PMID:27183218 doi:http://dx.doi.org/10.1016/j.trsl.2016.04.006
- ↑ Lee EY, Lee ZH, Song YW. CXCL10 and autoimmune diseases. Autoimmun Rev. 2009 Mar;8(5):379-83. doi: 10.1016/j.autrev.2008.12.002. Epub 2008, Dec 25. PMID:19105984 doi:http://dx.doi.org/10.1016/j.autrev.2008.12.002
- ↑ Chatterjee M, Gawaz M. Platelet-derived CXCL12 (SDF-1alpha): basic mechanisms and clinical implications. J Thromb Haemost. 2013 Nov;11(11):1954-67. doi: 10.1111/jth.12404. PMID:24024928 doi:http://dx.doi.org/10.1111/jth.12404
- ↑ van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, Farina GA, Stifano G, Mathes AL, Cossu M, York M, Collins C, Wenink M, Huijbens R, Hesselstrand R, Saxne T, DiMarzio M, Wuttge D, Agarwal SK, Reveille JD, Assassi S, Mayes M, Deng Y, Drenth JP, de Graaf J, den Heijer M, Kallenberg CG, Bijl M, Loof A, van den Berg WB, Joosten LA, Smith V, de Keyser F, Scorza R, Lunardi C, van Riel PL, Vonk M, van Heerde W, Meller S, Homey B, Beretta L, Roest M, Trojanowska M, Lafyatis R, Radstake TR. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med. 2014 Jan 30;370(5):433-43. doi: 10.1056/NEJMoa1114576. Epub 2013, Dec 18. PMID:24350901 doi:http://dx.doi.org/10.1056/NEJMoa1114576
- ↑ Havens AM, Chiu E, Taba M, Wang J, Shiozawa Y, Jung Y, Taichman LS, D'Silva NJ, Gopalakrishnan R, Wang C, Giannobile WV, Taichman RS. Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease. J Periodontol. 2008 May;79(5):845-53. doi: 10.1902/jop.2008.070514. PMID:18454663 doi:http://dx.doi.org/10.1902/jop.2008.070514
