D-alanine-D-alanine ligase

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DDL structure contains <scene name='55/552270/Cv/5'>3 α/β domains</scene> ({{Template:ColorKey_Helix}},{{Template:ColorKey_Strand}},{{Template:ColorKey_Loop}}, {{Template:ColorKey_Turn}}). The <scene name='55/552270/Cv/6'>ADP-binding site</scene> is found between domains 1 and 2.<ref>PMID:17015835</ref>
DDL structure contains <scene name='55/552270/Cv/5'>3 α/β domains</scene> ({{Template:ColorKey_Helix}},{{Template:ColorKey_Strand}},{{Template:ColorKey_Loop}}, {{Template:ColorKey_Turn}}). The <scene name='55/552270/Cv/6'>ADP-binding site</scene> is found between domains 1 and 2.<ref>PMID:17015835</ref>
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==3D structures of D-alanine-D-alanine ligase==
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[[D-alanine-D-alanine ligase 3D structures]]
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</StructureSection>
</StructureSection>
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**[[3tqt]] – DDL – ''Coxiella burnetii''<br />
**[[3tqt]] – DDL – ''Coxiella burnetii''<br />
**[[3v4z]], [[4zqi]] – DDL – ''Yersinia pestis'' <br />
**[[3v4z]], [[4zqi]] – DDL – ''Yersinia pestis'' <br />
-
**[[4egq]] – DDL – ''Burkholderia pseudomallei'' <br />
+
**[[4egq]] – BpDDL – ''Burkholderia pseudomallei'' <br />
**[[4egj]] – DDL – ''Burkholderia xenovorans'' <br />
**[[4egj]] – DDL – ''Burkholderia xenovorans'' <br />
**[[4eg0]] – DDL – ''Burkholderia ambifaria'' <br />
**[[4eg0]] – DDL – ''Burkholderia ambifaria'' <br />
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**[[3i12]] – StDDL – ''Salmonella typhimurium''<br />
**[[3i12]] – StDDL – ''Salmonella typhimurium''<br />
**[[5d8d]], [[5dmx]] – DDL – ''Acinetobacter baumannii'' <br />
**[[5d8d]], [[5dmx]] – DDL – ''Acinetobacter baumannii'' <br />
 +
**[[6dgi]] – DDL – Vibrio cholerae <br />
-
*D-alanine-D-alanine ligase complex
+
*D-alanine-D-alanine ligase binary complex
**[[2i8c]] – SaDDL + ADP <br />
**[[2i8c]] – SaDDL + ADP <br />
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**[[2yzm]] – TtDDL + D-alanine <br />
**[[2yzm]] – TtDDL + D-alanine <br />
**[[2yzn]] – TtDDL + AMPPNP <br />
**[[2yzn]] – TtDDL + AMPPNP <br />
-
**[[2zdh]] – TtDDL + D-alanine + ADP<br />
 
-
**[[2zdq]] – TtDDL + D-alanine + ATP<br />
 
**[[3r5x]] – BaDDL + ATP <br />
**[[3r5x]] – BaDDL + ATP <br />
**[[3q1k]] – StDDL + ADP <br />
**[[3q1k]] – StDDL + ADP <br />
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**[[5bph]] – YpDDL + AMP <br />
**[[5bph]] – YpDDL + AMP <br />
**[[5c1o]] – YpDDL + AMPPNP <br />
**[[5c1o]] – YpDDL + AMPPNP <br />
-
**[[5c1p]] – YpDDL + D-alanine-D-alanine + ADP<br />
+
**[[5nrh]] – BpDDL + AMP <br />
**[[4fu0]] – DDL + ADP – ''Enterococcus faecalis''<br />
**[[4fu0]] – DDL + ADP – ''Enterococcus faecalis''<br />
**[[4l1k]] – XoDDL + AMPPNP <br />
**[[4l1k]] – XoDDL + AMPPNP <br />
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**[[3rfc]] – XoDDL (mutant) + ADP <br />
**[[3rfc]] – XoDDL (mutant) + ADP <br />
**[[3r5f]] – XoDDL (mutant) + ATP <br />
**[[3r5f]] – XoDDL (mutant) + ATP <br />
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*D-alanine-D-alanine ligase ternary complex
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 +
**[[2zdh]] – TtDDL + D-alanine + ADP<br />
 +
**[[2zdq]] – TtDDL + D-alanine + ATP<br />
 +
**[[5nri]] – BpDDL + D-alanine-D-alanine + AMP<br />
 +
**[[5c1p]] – YpDDL + D-alanine-D-alanine + ADP<br />
**[[1iov]] – EcDDL + ADP + phosphoryl phosphonate <br />
**[[1iov]] – EcDDL + ADP + phosphoryl phosphonate <br />
**[[1iow]] – EcDDL (mutant) + ADP + phosphoryl phosphonate <br />
**[[1iow]] – EcDDL (mutant) + ADP + phosphoryl phosphonate <br />

Revision as of 08:26, 3 June 2019

Structure of D-alanine-D-alanine ligase dimer complex with ADP (stick model), sulfate and Mg+2 ion (green) (PDB entry 2i8c)

Drag the structure with the mouse to rotate

3D structures of D-alanine-D-alanine ligase

Updated on 03-June-2019

References

  1. ↑ Fan C, Moews PC, Walsh CT, Knox JR. Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution. Science. 1994 Oct 21;266(5184):439-43. PMID:7939684
  2. ↑ Liu S, Chang JS, Herberg JT, Horng MM, Tomich PK, Lin AH, Marotti KR. Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15178-83. Epub 2006 Oct 2. PMID:17015835

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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