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Deaminase
From Proteopedia
(Difference between revisions)
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The <scene name='55/551217/Cv/3'>active site of cytosine deaminase contains a catalytically active zinc</scene> atom.<ref>PMID:12906827</ref> | The <scene name='55/551217/Cv/3'>active site of cytosine deaminase contains a catalytically active zinc</scene> atom.<ref>PMID:12906827</ref> | ||
| + | |||
| + | == 3D Structures of deaminase == | ||
| + | [[Deaminase 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
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**[[1p6o]] – yCDDA + pyrimidine derivative<BR /> | **[[1p6o]] – yCDDA + pyrimidine derivative<BR /> | ||
**[[2o3k]] – yCDDA (mutant) + pyrimidine derivative<BR /> | **[[2o3k]] – yCDDA (mutant) + pyrimidine derivative<BR /> | ||
| - | **[[4r7w]], [[4r85]], [[4r88]] – | + | **[[4r7w]], [[4r85]], [[4r88]] – KpCDDA + cytosine derivative – ''Klebsiella pneumoniae''<BR /> |
* Deoxycytidylate deaminase | * Deoxycytidylate deaminase | ||
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**[[1jt9]] – EcGPD (mutant) <BR /> | **[[1jt9]] – EcGPD (mutant) <BR /> | ||
**[[2ri0]] – SmGPD – ''Streptococcus mutans'' <BR /> | **[[2ri0]] – SmGPD – ''Streptococcus mutans'' <BR /> | ||
| + | **[[6nbg]] – KpGPD <BR /> | ||
**[[3hn6]] – GPD – ''Borrelia burgdorferi''<br /> | **[[3hn6]] – GPD – ''Borrelia burgdorferi''<br /> | ||
**[[1j5x]] – GPD – ''Thermotoga maritima''<br /> | **[[1j5x]] – GPD – ''Thermotoga maritima''<br /> | ||
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**[[5fjn]] – PmLSD + anthranilate <BR /> | **[[5fjn]] – PmLSD + anthranilate <BR /> | ||
**[[5i39]], [[5hxw]] – LSD + FAD – ''Proteus vulgaris'' <BR /> | **[[5i39]], [[5hxw]] – LSD + FAD – ''Proteus vulgaris'' <BR /> | ||
| + | |||
| + | *2-aminomuconate deaminase | ||
| + | |||
| + | **[[6izh]] – PsAMD – <BR /> | ||
| + | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:39, 3 June 2019
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3D Structures of deaminase
Updated on 03-June-2019
References
- ↑ Bransteitter R, Pham P, Scharff MD, Goodman MF. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4102-7. Epub 2003 Mar 21. PMID:12651944 doi:http://dx.doi.org/10.1073/pnas.0730835100
- ↑ Egeblad L, Welin M, Flodin S, Graslund S, Wang L, Balzarini J, Eriksson S, Nordlund P. Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism. PLoS One. 2012;7(5):e37724. Epub 2012 May 25. PMID:22662200 doi:10.1371/journal.pone.0037724
- ↑ Negroni L, Samson M, Guigonis JM, Rossi B, Pierrefite-Carle V, Baudoin C. Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation. Mol Cancer Ther. 2007 Oct;6(10):2747-56. PMID:17938268 doi:http://dx.doi.org/10.1158/1535-7163.MCT-07-0040
- ↑ Ireton GC, Black ME, Stoddard BL. The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure. 2003 Aug;11(8):961-72. PMID:12906827
