6aax

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'''Unreleased structure'''
 
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The entry 6aax is ON HOLD until Paper Publication
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==Crystal structure of TFB1M and h45 with SAM in homo sapiens==
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<StructureSection load='6aax' size='340' side='right'caption='[[6aax]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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Authors: Liu, X., Shen, S., Wu, P., Li, F., Gong, Q., Wu, J., Zhang, H., Shi, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6aax]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AAX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AAX FirstGlance]. <br>
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Description: Crystal structure of TFB1M and h45 with SAM in homo sapiens
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aax OCA], [http://pdbe.org/6aax PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aax RCSB], [http://www.ebi.ac.uk/pdbsum/6aax PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aax ProSAT]</span></td></tr>
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[[Category: Wu, J]]
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</table>
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[[Category: Zhang, H]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/TFB1M_HUMAN TFB1M_HUMAN]] Mitochondrial non-syndromic sensorineural deafness. Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.
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== Function ==
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[[http://www.uniprot.org/uniprot/TFB1M_HUMAN TFB1M_HUMAN]] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.<ref>PMID:11809803</ref> <ref>PMID:12068295</ref> <ref>PMID:12897151</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gong, Q]]
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[[Category: Li, F]]
[[Category: Liu, X]]
[[Category: Liu, X]]
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[[Category: Gong, Q]]
 
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[[Category: Wu, P]]
 
[[Category: Shen, S]]
[[Category: Shen, S]]
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[[Category: Li, F]]
 
[[Category: Shi, Y]]
[[Category: Shi, Y]]
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[[Category: Wu, J]]
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[[Category: Wu, P]]
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[[Category: Zhang, H]]
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[[Category: H45]]
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[[Category: Tfb1m]]
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[[Category: Transferase-rna complex]]

Revision as of 22:41, 5 June 2019

Crystal structure of TFB1M and h45 with SAM in homo sapiens

PDB ID 6aax

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