6k0x

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m (Protected "6k0x" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6k0x is ON HOLD
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==Structure of N6AMT1-TRMT112 Complex with SAM==
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<StructureSection load='6k0x' size='340' side='right'caption='[[6k0x]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Guo, Q., Liao, S., Xu, C., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6k0x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K0X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K0X FirstGlance]. <br>
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Description: Structure of N6AMT1-TRMT112 Complex with SAM
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k0x OCA], [http://pdbe.org/6k0x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k0x RCSB], [http://www.ebi.ac.uk/pdbsum/6k0x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k0x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/N6MT1_HUMAN N6MT1_HUMAN]] Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146) (By similarity). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008). Also acts as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:30017583). N(6)-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation (PubMed:30017583). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655).[UniProtKB:Q6SKR2]<ref>PMID:18539146</ref> <ref>PMID:20606008</ref> <ref>PMID:21193388</ref> <ref>PMID:25997655</ref> <ref>PMID:30017583</ref> [[http://www.uniprot.org/uniprot/TR112_HUMAN TR112_HUMAN]] Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604).<ref>PMID:18539146</ref> <ref>PMID:20308323</ref> <ref>PMID:25851604</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Guo, Q]]
[[Category: Guo, Q]]
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[[Category: Liao, S]]
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[[Category: Structural genomic]]
[[Category: Xu, C]]
[[Category: Xu, C]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Complex]]
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[[Category: Liao, S]]
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[[Category: Gene regulation]]
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[[Category: Methylase]]
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[[Category: Sgc]]

Revision as of 22:47, 5 June 2019

Structure of N6AMT1-TRMT112 Complex with SAM

PDB ID 6k0x

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