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6o3x

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'''Unreleased structure'''
 
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The entry 6o3x is ON HOLD until Paper Publication
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==Crystal structure of yeast Nrd1 CID in complex with Sen1 NIM2==
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<StructureSection load='6o3x' size='340' side='right'caption='[[6o3x]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6o3x]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O3X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6o3w|6o3w]], [[6o3y|6o3y]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o3x OCA], [http://pdbe.org/6o3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o3x RCSB], [http://www.ebi.ac.uk/pdbsum/6o3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o3x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NRD1_YEAST NRD1_YEAST]] Plays a role in sequence-specific regulation of nuclear pre-mRNA abundance. [[http://www.uniprot.org/uniprot/SEN1_YEAST SEN1_YEAST]] ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs. Directs RNA polymerase II transcription termination on snoRNAs as well as on several short protein-coding genes. May also play a role in transcription-coupled nucleotide excision repair.<ref>PMID:11565036</ref> <ref>PMID:15121901</ref> <ref>PMID:17157256</ref> <ref>PMID:8943355</ref> <ref>PMID:9365256</ref> <ref>PMID:9819377</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The Nrd1-Nab3-Sen1 (NNS) complex carries out the transcription termination of non-coding RNAs (ncRNAs) by RNA polymerase II (Pol II) in yeast, although the detailed interactions among its subunits remain obscure. Here we have identified three sequence motifs in Sen1 that mediate direct interactions with the Pol II CTD interaction domain (CID) of Nrd1, determined the crystal structures of these Nrd1 interaction motifs (NIMs) bound to the CID, and characterized the interactions in vitro and in yeast. Removal of all three NIMs abolishes NNS complex formation and gives rise to ncRNA termination defects.
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Authors:
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Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1.,Zhang Y, Chun Y, Buratowski S, Tong L Structure. 2019 Apr 23. pii: S0969-2126(19)30127-3. doi:, 10.1016/j.str.2019.04.005. PMID:31104813<ref>PMID:31104813</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 6o3x" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Tong, L]]
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[[Category: Zhang, Y]]
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[[Category: Cid]]
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[[Category: Complex]]
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[[Category: Ctd mimic]]
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[[Category: Transcription]]

Revision as of 22:50, 5 June 2019

Crystal structure of yeast Nrd1 CID in complex with Sen1 NIM2

PDB ID 6o3x

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