4xqr
From Proteopedia
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==Crystal structure of unliganded human FPPS at 2.15 angstrom resolution== | ==Crystal structure of unliganded human FPPS at 2.15 angstrom resolution== | ||
| - | <StructureSection load='4xqr' size='340' side='right' caption='[[4xqr]], [[Resolution|resolution]] 2.15Å' scene=''> | + | <StructureSection load='4xqr' size='340' side='right'caption='[[4xqr]], [[Resolution|resolution]] 2.15Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4xqr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQR FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4xqr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQR FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xqs|4xqs]], [[4xqt|4xqt]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xqs|4xqs]], [[4xqt|4xqt]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqr OCA], [http://pdbe.org/4xqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xqr RCSB], [http://www.ebi.ac.uk/pdbsum/4xqr PDBsum]</span></td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqr OCA], [http://pdbe.org/4xqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xqr RCSB], [http://www.ebi.ac.uk/pdbsum/4xqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
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| + | ==See Also== | ||
| + | *[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Berghuis, A M]] | [[Category: Berghuis, A M]] | ||
[[Category: Park, J]] | [[Category: Park, J]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 23:41, 5 June 2019
Crystal structure of unliganded human FPPS at 2.15 angstrom resolution
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