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4y42

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Revision as of 00:02, 6 June 2019

Cyanase (CynS) from Serratia proteamaculans

Structural highlights

4y42 is a 10 chain structure with sequence from Serratia proteamaculans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:	Cyanase, with EC number 4.2.1.104
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CYNS_SERP5] Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

Publication Abstract from PubMed

Cyanate hydratase (CynS) catalyzes the decomposition of cyanate and bicarbonate into ammonia and carbon dioxide. Here, the serendipitous crystallization of CynS from Serratia proteamaculans (SpCynS) is reported. SpCynS was crystallized as an impurity and its identity was determined using mass-spectrometric analysis. The crystals belonged to space group P1 and diffracted to 2.1 A resolution. The overall structure of SpCynS is very similar to a previously determined structure of CynS from Escherichia coli. Density for a ligand bound to the SpCynS active site was observed, but could not be unambiguously identified. Additionally, glycerol molecules bound at the entry to the active site of the enzyme indicate conserved residues that might be important for the trafficking of substrates and products.

Serendipitous crystallization and structure determination of cyanase (CynS) from Serratia proteamaculans.,Butryn A, Stoehr G, Linke-Winnebeck C, Hopfner KP Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):471-6. doi:, 10.1107/S2053230X15004902. Epub 2015 Mar 21. PMID:25849512^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Butryn A, Stoehr G, Linke-Winnebeck C, Hopfner KP. Serendipitous crystallization and structure determination of cyanase (CynS) from Serratia proteamaculans. Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):471-6. doi:, 10.1107/S2053230X15004902. Epub 2015 Mar 21. PMID:25849512 doi:http://dx.doi.org/10.1107/S2053230X15004902

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4y42"

@@ Line 1: / Line 1: @@
 ==Cyanase (CynS) from Serratia proteamaculans==
-<StructureSection load='4y42' size='340' side='right' caption='[[4y42]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
+<StructureSection load='4y42' size='340' side='right'caption='[[4y42]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[4y42]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Serratia_proteamaculans Serratia proteamaculans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y42 FirstGlance]. <br>
@@ Line 24: / Line 24: @@
 </StructureSection>
 [[Category: Cyanase]]
+[[Category: Large Structures]]
 [[Category: Serratia proteamaculans]]
 [[Category: Butryn, A]]

4y42

From Proteopedia

Revision as of 00:02, 6 June 2019

Cyanase (CynS) from Serratia proteamaculans

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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