Dihydroorotate dehydrogenase
From Proteopedia
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== Relevance == | == Relevance == | ||
| - | Leflunomide and brequinar are anti-rheumatic | + | Leflunomide and brequinar are anti-rheumatic drugs which bind to DHOD. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 07:58, 10 June 2019
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3D Structures of dihydroorotate dehydrogenase
Updated on 10-June-2019
References
- ↑ Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL. On dihydroorotate dehydrogenases and their inhibitors and uses. J Med Chem. 2013 Apr 25;56(8):3148-67. doi: 10.1021/jm301848w. Epub 2013 Mar 20. PMID:23452331 doi:http://dx.doi.org/10.1021/jm301848w
- ↑ Hurt DE, Sutton AE, Clardy J. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1610-5. Epub 2006 Jan 10. PMID:16406782 doi:S0960-894X(05)01599-4
