Dihydroorotate dehydrogenase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of dihydroorotate dehydrogenase == | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Dihydroorotate dehydrogenase | ||
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| - | **[[1dor]], [[1jue]] – LlDHOD A – ''Lactococcus lactis''<br /> | ||
| - | **[[1jub]] – LlDHOD A (mutant) <br /> | ||
| - | **[[1ep1]], [[1ep3]] – LlDHOD B<br /> | ||
| - | **[[5ksw]] – LlDHOD A+B (mutant)<br /> | ||
| - | **[[2djx]], [[3c3n]] – TcDHOD – ''Trypanosoma cruzi''<br /> | ||
| - | **[[3tjx]], [[3tro]], [[6tgx]] – LmDHOD (mutant) – ''Leishmania major''<br /> | ||
| - | **[[4wzh]] – DHOD – ''Leishmania braziliensis''<br /> | ||
| - | **[[4zq6]] – DHOD – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[4ylf]], [[4yry]] – DHOD A+B – ''Thermotoga maritima''<br /> | ||
| - | **[[6b8s]] – DHODH + FMN – ''Helicobacter pylori''<br /> | ||
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| - | *DHOD binary complex | ||
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| - | **[[3kvj]], [[3kvk]], [[3kvl]], [[3kvm]] – hDHOD + inhibitor - human<br /> | ||
| - | **[[2bxv]] – hDHOD + orotate<br /> | ||
| - | **[[2e68]] – hDHOD + dihydroorotate<br /> | ||
| - | **[[2dor]] - LlDHOD A + orotate <br /> | ||
| - | **[[1jqv]], [[1jqx]], [[1jrb]], [[1jrc]], [[1ovd]] – LlDHOD A (mutant) + orotate <br /> | ||
| - | **[[2bsl]], [[2bx7]] – LlDHOD A + pyrimidine analog <br /> | ||
| - | **[[1ep2]], [[1ue9]] – LlDHOD B+ orotate <br /> | ||
| - | **[[2djl]] – TcDHOD + succinate <br /> | ||
| - | **[[2e6a]] - TcDHOD + orotate derivative<br /> | ||
| - | **[[2e6d]] – TcDHOD + fumarate <br /> | ||
| - | **[[2e6f]] – TcDHOD + oxonate <br /> | ||
| - | **[[2b4g]] – TbDHOD + orotate – ''Trypanosoma brucei''<br /> | ||
| - | **[[3c61]] – DHOD + orotate – ''Leishmania donovani''<br /> | ||
| - | **[[3mhu]], [[3mjy]] – LmDHOD + orotate derivative <br /> | ||
| - | **[[3tq0]] – LmDHOD + fumarate <br /> | ||
| - | **[[4ef8]], [[4ef9]] – LmDHOD + cyanate derivative<br /> | ||
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| - | * Dihydroorotate dehydrogenase (quinone) | ||
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| - | **[[3kvj]], [[3kvk]], [[3kvl]], [[3kvm]] – hDHODH + inhibitor<br /> | ||
| - | **[[1d3h]] – hDHODH + orotate + cell growth retarding drug <br /> | ||
| - | **[[4igh]] - hDHODH + quinoline derivative<br /> | ||
| - | **[[3f1q]], [[3fj6]], [[3fjl]], [[3g0u]], [[3g0x]] – hDHODH + orotate + leflunomide<br /> | ||
| - | **[[3w7r]], [[3u2o]], [[3zws]], [[3zwt]], [[4jgd]], [[4js3]], [[4jts]], [[1d3g]], [[1uuo]], [[2b0m]], [[2fpt]], [[2fpv]], [[2fpy]], [[2fqi]], [[2wv8]], [[4jtt]], [[4jtu]], [[4ls0]], [[4ls1]], [[4ls2]], [[4oqv]], [[4rk8]], [[4rka]], [[4rli]], [[4rr4]], [[4ylw]], [[4zl1]], [[4zmg]], [[5h2z]], [[5hin]], [[5hqe]], [[5k9c]], [[5k9d]], [[5mut]], [[5mvc]], [[5mvd]], [[5h73]][[5zf9]], [[6cjg]], [[6et4]], [[5zf4]], [[5zf7]], [[5zf8]], [[5zfa]], [[5zfb]], [[6cjf]], [[6fmd]], [[6qu7] – hDHODH + orotate + inhibitor<br /> | ||
| - | **[[2prl]], [[2prm]], [[2prh]] – hDHODH (mutant) + orotate + inhibitor<br /> | ||
| - | **[[6et4]] – hDHODH + FMN + inhibitor<br /> | ||
| - | **[[4ori]] – rDHODH + orotate + inhibitor - rat<br /> | ||
| - | **[[1uum]] – rDHODH + orotate + drug<br /> | ||
| - | **[[1tv5]], [[3i65]], [[3i68]], [[3i6r]], [[3o8a]], [[3sfk]], [[4cq8]], [[4cq9]], [[4cqa]], [[4orm]], [[4rx0]], [[5boo]], [[5fi8]], [[6i55]], [[6gjg]], [[6i4b]] - PfDHODH + orotate + inhibitor – ''Plasmodium falciparum''<br /> | ||
| - | **[[5del]], [[5tbo]], [[6e0b]] – PfDHODH (mutant) + orotate + inhibitor <br /> | ||
| - | **[[1f76]] – DHODH + orotate – ''Escherichia coli''<br /> | ||
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| - | * Dihydroorotate dehydrogenase (fumarate) | ||
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| - | **[[3w6y]], [[3w70]], [[3w71]], [[3w70]], [[3w71]], [[3w72]], [[3w73]], [[3w74]], [[3w75]], [[3w76]], [[3w7c]], [[3w7d]], [[3w7e]], [[3w7g]], [[3w7h]], [[3w7i]], [[3w7j]], [[3w7k]], [[3w7l]], [[3w7m]], [[3w7n]], [[3w7o]], [[3w7p]], [[3w7q]], [[3w83]], [[3w84]], [[3w85]], [[3w86]], [[3w87]], [[3w88]], [[4jd4]], [[4jdb]], [[3w1q]], [[3w1r]], [[3w1t]], [[3w1u]], [[3w1x]], [[3w22]], [[3w23]], [[3w2j]], [[3w2k]], [[3w2l]], [[3w2m]], [[3w2n]], [[3w2u]], [[3w3o]], [[5e93]], [[5ea9]] – TcDHODF + inhibitor<br /> | ||
| - | **[[3w1p]] - TcDHODF + pyrimidine derivative<br /> | ||
| - | **[[3w1a]], [[3w1l]], [[3w1m]], [[3w1n]] - TcDHODF + orotate derivative<br /> | ||
| - | **[[5xfw]] - TbDHODF (mutant) + malonate<br /> | ||
| - | **[[5xfv]] - TbDHODF (mutant) + FMN + malonate<br /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:47, 10 June 2019
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References
- ↑ Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL. On dihydroorotate dehydrogenases and their inhibitors and uses. J Med Chem. 2013 Apr 25;56(8):3148-67. doi: 10.1021/jm301848w. Epub 2013 Mar 20. PMID:23452331 doi:http://dx.doi.org/10.1021/jm301848w
- ↑ Baumann P, Mandl-Weber S, Volkl A, Adam C, Bumeder I, Oduncu F, Schmidmaier R. Dihydroorotate dehydrogenase inhibitor A771726 (leflunomide) induces apoptosis and diminishes proliferation of multiple myeloma cells. Mol Cancer Ther. 2009 Feb;8(2):366-75. doi: 10.1158/1535-7163.MCT-08-0664. Epub, 2009 Jan 27. PMID:19174558 doi:http://dx.doi.org/10.1158/1535-7163.MCT-08-0664
- ↑ Hurt DE, Sutton AE, Clardy J. Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1610-5. Epub 2006 Jan 10. PMID:16406782 doi:S0960-894X(05)01599-4
