User:Bianca Perez Martins/Sandbox 1
From Proteopedia
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===FHA/BRCT-Repeat architecture=== | ===FHA/BRCT-Repeat architecture=== | ||
| - | <Structure load=' | + | <Structure load='3huf3' size='350' frame='true' align='right' caption='Flexibility of FHA/BRCT-Repeat region' scene='Flexibility animation' /> |
===FHA/BRCT-Repeat interacts with Ctp1=== | ===FHA/BRCT-Repeat interacts with Ctp1=== | ||
Revision as of 14:11, 10 June 2019
Contents |
Introduction
A keystone in the response to double strand breaks (DSBs) in eukaryotic cells is the MRN complex, one of the earliest repair factors to bind to DSBs. MRN complex participates in the resection of DNA double strand breaks and acts as a bridge to hold the DNA ends in close proximity and promote the next steps of DSB repair. MRN complex is formed by a dimer of Mre11, a dimer of Rad50 and a single NBS1 subunit. Mre11 acts as a nuclease and interacts directly with the DNA, Rad50 is a scaffolding component and cofactor, and NBS1 sinalizes for DNA damage response. However, Nbs1 also acts later in the repair process to regulate the DNA damage checkpoint and to recruit other repair factors to DSBs.
NBS1
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FHA/BRCT-Repeat architecture
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FHA/BRCT-Repeat interacts with Ctp1
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Your Heading Here (maybe something like 'Structure')
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</StructureSection>
