5zol
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a three sites mutantion of FSAA complexed with HA and product== | |
| - | + | <StructureSection load='5zol' size='340' side='right'caption='[[5zol]], [[Resolution|resolution]] 2.17Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5zol]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZOL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZOL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4Y8:1-HYDROXYPROPAN-2-ONE'>4Y8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LW1:thiophene-2-carbaldehyde'>LW1</scene>, <scene name='pdbligand=LW2:(3S,4S)-3,4-dihydroxy-4-(thiophen-2-yl)butan-2-one'>LW2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zol OCA], [http://pdbe.org/5zol PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zol RCSB], [http://www.ebi.ac.uk/pdbsum/5zol PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zol ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI]] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Wu, L]] | [[Category: Wu, L]] | ||
| - | [[Category: Yu, H | + | [[Category: Yang, X H]] |
| - | [[Category: Zhou, J | + | [[Category: Yu, H W]] |
| + | [[Category: Zhou, J H]] | ||
| + | [[Category: Acceptor]] | ||
| + | [[Category: Donor]] | ||
| + | [[Category: Flexible]] | ||
| + | [[Category: Fructose-6-phosphate aldolase]] | ||
| + | [[Category: Lyase]] | ||
| + | [[Category: Mutant]] | ||
Revision as of 05:23, 12 June 2019
Crystal structure of a three sites mutantion of FSAA complexed with HA and product
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Categories: Large Structures | Wu, L | Yang, X H | Yu, H W | Zhou, J H | Acceptor | Donor | Flexible | Fructose-6-phosphate aldolase | Lyase | Mutant
