6h9y
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens== | |
| - | + | <StructureSection load='6h9y' size='340' side='right'caption='[[6h9y]], [[Resolution|resolution]] 1.31Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6h9y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H9Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h9y OCA], [http://pdbe.org/6h9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h9y RCSB], [http://www.ebi.ac.uk/pdbsum/6h9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h9y ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A0A2K9UWM4_9REOV A0A2K9UWM4_9REOV]] Outer capsid protein VP5*: Forms the spike "foot" and "body" and acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. During entry, the part of VP5* that protrudes from the virus folds back on itself and reorganizes from a local dimer to a trimer. This reorganization may be linked to membrane penetration by exposing VP5* hydrophobic region. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS01043052] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Buesa, J]] | ||
| + | [[Category: Ciges-Tomas, J R]] | ||
| + | [[Category: Gozalbo-Rovira, R]] | ||
| + | [[Category: Marina, A]] | ||
[[Category: Monedero, V]] | [[Category: Monedero, V]] | ||
| - | [[Category: Ciges-Tomas, J.R]] | ||
| - | [[Category: Buesa, J]] | ||
[[Category: Rodriguez-Diaz, J]] | [[Category: Rodriguez-Diaz, J]] | ||
[[Category: Santiso-Bellon, C]] | [[Category: Santiso-Bellon, C]] | ||
| - | [[Category: Yebra, M.J]] | ||
[[Category: Vila-Vicent, S]] | [[Category: Vila-Vicent, S]] | ||
| - | [[Category: | + | [[Category: Yebra, M J]] |
| - | [[Category: | + | [[Category: Histo-blood group antigen rotavirus]] |
| + | [[Category: Viral protein]] | ||
Revision as of 05:33, 12 June 2019
Unraveling the role of the secretor antigen in human rotavirus attachment to histo-blood group antigens
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