6hyy
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human phosphoserine phosphatase with serine and phosphate== | |
| - | + | <StructureSection load='6hyy' size='340' side='right'caption='[[6hyy]], [[Resolution|resolution]] 1.57Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hyy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HYY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HYY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoserine_phosphatase Phosphoserine phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.3 3.1.3.3] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hyy OCA], [http://pdbe.org/6hyy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hyy RCSB], [http://www.ebi.ac.uk/pdbsum/6hyy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hyy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN]] Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:[http://omim.org/entry/614023 614023]]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.<ref>PMID:14673469</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN]] Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.<ref>PMID:12777757</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Phosphoserine phosphatase]] | ||
| + | [[Category: Haufroid, M]] | ||
[[Category: Mirgaux, M]] | [[Category: Mirgaux, M]] | ||
[[Category: Wouters, J]] | [[Category: Wouters, J]] | ||
| - | [[Category: | + | [[Category: Human phosphoserine phosphatase]] |
| + | [[Category: Hydrolase]] | ||
Revision as of 05:35, 12 June 2019
Human phosphoserine phosphatase with serine and phosphate
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