6og3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Focus classification structure of the hyperactive ClpB mutant K476C, bound to casein, NTD-trimer== | |
| - | + | <StructureSection load='6og3' size='340' side='right'caption='[[6og3]], [[Resolution|resolution]] 4.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6og3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OG3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OG3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6og1|6og1]], [[6og2|6og2]], [[6oax|6oax]], [[6oay|6oay]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6og3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6og3 OCA], [http://pdbe.org/6og3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6og3 RCSB], [http://www.ebi.ac.uk/pdbsum/6og3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6og3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CLPB_ECOLI CLPB_ECOLI]] Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.<ref>PMID:10982797</ref> <ref>PMID:12624113</ref> <ref>PMID:14640692</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bart, S M]] | ||
| + | [[Category: Castellano, L M]] | ||
| + | [[Category: Dimaio, F]] | ||
| + | [[Category: Gates, S N]] | ||
| + | [[Category: Lin, J B]] | ||
| + | [[Category: Rizo, A R]] | ||
[[Category: Shorter, J]] | [[Category: Shorter, J]] | ||
| - | [[Category: | + | [[Category: Southworth, D R]] |
| - | + | ||
[[Category: Tse, E]] | [[Category: Tse, E]] | ||
| - | [[Category: | + | [[Category: Aaa+]] |
| - | [[Category: | + | [[Category: Chaperone]] |
| - | [[Category: | + | [[Category: Clpb]] |
| - | [[Category: | + | [[Category: Disaggregase]] |
Revision as of 05:43, 12 June 2019
Focus classification structure of the hyperactive ClpB mutant K476C, bound to casein, NTD-trimer
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Categories: Bos taurus | Large Structures | Bart, S M | Castellano, L M | Dimaio, F | Gates, S N | Lin, J B | Rizo, A R | Shorter, J | Southworth, D R | Tse, E | Aaa+ | Chaperone | Clpb | Disaggregase
