6q2z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR solution structure of the HVO_2922 protein from Haloferax volcanii== | |
| + | <StructureSection load='6q2z' size='340' side='right'caption='[[6q2z]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6q2z]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q2Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q2z OCA], [http://pdbe.org/6q2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q2z RCSB], [http://www.ebi.ac.uk/pdbsum/6q2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q2z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Past sequencing campaigns overlooked small proteins as they seemed to be irrelevant due to their small size. However, their occurrence is widespread and there is growing evidence that these small proteins are in fact functionally very important in organisms found in all kingdoms of life. Within a global proteome analysis for small proteins of the archaeal model organism Haloferax volcanii, the HVO_2922 protein has been identified. It is differentially expressed in response to changes in iron and salt concentrations, suggesting that its expression is stress-regulated. The protein is conserved among Haloarchaea and contains an uncharacterized domain of unknown function (DUF1508, UPF0339 family protein). We elucidated the NMR solution structure, which shows that the isolated protein forms a symmetrical dimer. The dimerization is found to be concentration-dependent and essential for the protein stability and most likely for its functionality as mutagenesis at the dimer interface leads to a decrease of stability and protein aggregation. | ||
| - | + | Solution structure and dynamics of the small protein HVO_2922 from Haloferax volcanii.,Kubatova N, Jonker HRA, Saxena K, Richter C, Vogel V, Schreiber S, Marchfelder A, Schwalbe H Chembiochem. 2019 Jun 4. doi: 10.1002/cbic.201900085. PMID:31161645<ref>PMID:31161645</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6q2z" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Jonker, H R.A]] | ||
[[Category: Kubatova, N]] | [[Category: Kubatova, N]] | ||
[[Category: Marchfelder, A]] | [[Category: Marchfelder, A]] | ||
| - | [[Category: Jonker, H.R.A]] | ||
| - | [[Category: Saxena, K]] | ||
[[Category: Richter, C]] | [[Category: Richter, C]] | ||
| + | [[Category: Saxena, K]] | ||
[[Category: Schwalbe, H]] | [[Category: Schwalbe, H]] | ||
| + | [[Category: Conserved hypothetical protein]] | ||
| + | [[Category: Unknown function]] | ||
Revision as of 05:45, 12 June 2019
NMR solution structure of the HVO_2922 protein from Haloferax volcanii
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