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6q6j
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human phosphoserine phosphatase with substrate analogue homo-cysteic acid== | |
| - | + | <StructureSection load='6q6j' size='340' side='right'caption='[[6q6j]], [[Resolution|resolution]] 1.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6q6j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q6J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q6J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HJT:(2~{S})-2-azanyl-4-sulfo-butanoic+acid'>HJT</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoserine_phosphatase Phosphoserine phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.3 3.1.3.3] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q6j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q6j OCA], [http://pdbe.org/6q6j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q6j RCSB], [http://www.ebi.ac.uk/pdbsum/6q6j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q6j ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN]] Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:[http://omim.org/entry/614023 614023]]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.<ref>PMID:14673469</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN]] Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.<ref>PMID:12777757</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Phosphoserine phosphatase]] | ||
| + | [[Category: Haufroid, M]] | ||
[[Category: Mirgaux, M]] | [[Category: Mirgaux, M]] | ||
[[Category: Wouters, J]] | [[Category: Wouters, J]] | ||
| - | [[Category: | + | [[Category: Human phosphoserine phosphatase]] |
| + | [[Category: Hydrolase]] | ||
Revision as of 05:45, 12 June 2019
Human phosphoserine phosphatase with substrate analogue homo-cysteic acid
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