This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6qg8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human Bcl-2 in complex with PUMA BH3 peptide== | |
| - | + | <StructureSection load='6qg8' size='340' side='right'caption='[[6qg8]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qg8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QG8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qfm|6qfm]], [[6qfi|6qfi]], [[6qgg|6qgg]], [[6qgk|6qgk]], [[6qgh|6qgh]], [[6qgj|6qgj]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qg8 OCA], [http://pdbe.org/6qg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qg8 RCSB], [http://www.ebi.ac.uk/pdbsum/6qg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qg8 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> [[http://www.uniprot.org/uniprot/BBC3_HUMAN BBC3_HUMAN]] Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.<ref>PMID:11463391</ref> <ref>PMID:23340338</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Casara, P]] | ||
[[Category: Chen, I]] | [[Category: Chen, I]] | ||
| - | [[Category: Williamson, D.S]] | ||
| - | [[Category: Smith, J]] | ||
| - | [[Category: Le Diguarher, T]] | ||
| - | [[Category: Matassova, N]] | ||
[[Category: Davidson, J]] | [[Category: Davidson, J]] | ||
| - | [[Category: Wang, Y]] | ||
| - | [[Category: Roughley, S]] | ||
| - | [[Category: Walmsley, C]] | ||
| - | [[Category: Graham, C.J]] | ||
| - | [[Category: Hubbard, R.E]] | ||
[[Category: Davis, B]] | [[Category: Davis, B]] | ||
| + | [[Category: Diguarher, T Le]] | ||
| + | [[Category: Dokurno, P]] | ||
| + | [[Category: Geneste, O]] | ||
| + | [[Category: Graham, C J]] | ||
| + | [[Category: Harris, R]] | ||
[[Category: Hickman, J]] | [[Category: Hickman, J]] | ||
| + | [[Category: Hubbard, R E]] | ||
| + | [[Category: Jordan, A M]] | ||
| + | [[Category: Kotschy, A]] | ||
| + | [[Category: Matassova, N]] | ||
| + | [[Category: Murray, J]] | ||
| + | [[Category: Pedder, C]] | ||
| + | [[Category: Ray, S]] | ||
| + | [[Category: Roughley, S]] | ||
| + | [[Category: Smith, J]] | ||
[[Category: Stark, J]] | [[Category: Stark, J]] | ||
| + | [[Category: Walmsley, C]] | ||
| + | [[Category: Wang, Y]] | ||
[[Category: Whitehead, N]] | [[Category: Whitehead, N]] | ||
| - | [[Category: | + | [[Category: Williamson, D S]] |
| - | [[Category: | + | [[Category: Apoptosis]] |
| - | [[Category: | + | [[Category: Bcl2]] |
| - | [[Category: | + | [[Category: Mcl1]] |
| - | [[Category: | + | [[Category: Puma]] |
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 05:46, 12 June 2019
Structure of human Bcl-2 in complex with PUMA BH3 peptide
| |||||||||||
Categories: Large Structures | Casara, P | Chen, I | Davidson, J | Davis, B | Diguarher, T Le | Dokurno, P | Geneste, O | Graham, C J | Harris, R | Hickman, J | Hubbard, R E | Jordan, A M | Kotschy, A | Matassova, N | Murray, J | Pedder, C | Ray, S | Roughley, S | Smith, J | Stark, J | Walmsley, C | Wang, Y | Whitehead, N | Williamson, D S | Apoptosis | Bcl2 | Mcl1 | Puma
