6qgk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human Bcl-2 in complex with THIQ-phenyl pyrazole compound== | |
| - | + | <StructureSection load='6qgk' size='340' side='right'caption='[[6qgk]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6qgk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QGK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=J1Q:1-[2-[[(3~{S})-3-(aminomethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]phenyl]-~{N},~{N}-dibutyl-5-methyl-pyrazole-3-carboxamide'>J1Q</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6qg8|6qg8]], [[6qgg|6qgg]], [[6qgh|6qgh]], [[6qgj|6qgj]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qgk OCA], [http://pdbe.org/6qgk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qgk RCSB], [http://www.ebi.ac.uk/pdbsum/6qgk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qgk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Casara, P]] | ||
[[Category: Chen, I]] | [[Category: Chen, I]] | ||
| - | [[Category: Williamson, D.S]] | ||
| - | [[Category: Smith, J]] | ||
| - | [[Category: Le Diguarher, T]] | ||
| - | [[Category: Matassova, N]] | ||
[[Category: Davidson, J]] | [[Category: Davidson, J]] | ||
| - | [[Category: Wang, Y]] | ||
| - | [[Category: Roughley, S]] | ||
| - | [[Category: Walmsley, C]] | ||
| - | [[Category: Graham, C.J]] | ||
| - | [[Category: Hubbard, R.E]] | ||
[[Category: Davis, B]] | [[Category: Davis, B]] | ||
| + | [[Category: Diguarher, T Le]] | ||
| + | [[Category: Dokurno, P]] | ||
| + | [[Category: Geneste, O]] | ||
| + | [[Category: Graham, C J]] | ||
| + | [[Category: Harris, R]] | ||
[[Category: Hickman, J]] | [[Category: Hickman, J]] | ||
| + | [[Category: Hubbard, R E]] | ||
| + | [[Category: Jordan, A M]] | ||
| + | [[Category: Kotschy, A]] | ||
| + | [[Category: Matassova, N]] | ||
| + | [[Category: Murray, J]] | ||
| + | [[Category: Pedder, C]] | ||
| + | [[Category: Ray, S]] | ||
| + | [[Category: Roughley, S]] | ||
| + | [[Category: Smith, J]] | ||
[[Category: Stark, J]] | [[Category: Stark, J]] | ||
| + | [[Category: Walmsley, C]] | ||
| + | [[Category: Wang, Y]] | ||
[[Category: Whitehead, N]] | [[Category: Whitehead, N]] | ||
| - | [[Category: | + | [[Category: Williamson, D S]] |
| - | [[Category: | + | [[Category: Apoptosis]] |
| - | [[Category: | + | [[Category: Bcl2]] |
| - | [[Category: | + | [[Category: Drug design]] |
| - | [[Category: | + | [[Category: Small molecule inhibitor]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structure of human Bcl-2 in complex with THIQ-phenyl pyrazole compound
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Categories: Large Structures | Casara, P | Chen, I | Davidson, J | Davis, B | Diguarher, T Le | Dokurno, P | Geneste, O | Graham, C J | Harris, R | Hickman, J | Hubbard, R E | Jordan, A M | Kotschy, A | Matassova, N | Murray, J | Pedder, C | Ray, S | Roughley, S | Smith, J | Stark, J | Walmsley, C | Wang, Y | Whitehead, N | Williamson, D S | Apoptosis | Bcl2 | Drug design | Small molecule inhibitor
