4yu2
From Proteopedia
(Difference between revisions)
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==Crystal structure of DYRK1A with harmine-derivatized AnnH-75 inhibitor== | ==Crystal structure of DYRK1A with harmine-derivatized AnnH-75 inhibitor== | ||
| - | <StructureSection load='4yu2' size='340' side='right' caption='[[4yu2]], [[Resolution|resolution]] 2.90Å' scene=''> | + | <StructureSection load='4yu2' size='340' side='right'caption='[[4yu2]], [[Resolution|resolution]] 2.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4yu2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YU2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4yu2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YU2 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4H5:(1-CHLORO-7-METHOXY-9H-BETA-CARBOLIN-9-YL)ACETONITRILE'>4H5</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4H5:(1-CHLORO-7-METHOXY-9H-BETA-CARBOLIN-9-YL)ACETONITRILE'>4H5</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DYRK1A, DYRK, MNB, MNBH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yu2 OCA], [http://pdbe.org/4yu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yu2 RCSB], [http://www.ebi.ac.uk/pdbsum/4yu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yu2 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yu2 OCA], [http://pdbe.org/4yu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yu2 RCSB], [http://www.ebi.ac.uk/pdbsum/4yu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yu2 ProSAT]</span></td></tr> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Dual-specificity kinase]] | [[Category: Dual-specificity kinase]] | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 07:22, 12 June 2019
Crystal structure of DYRK1A with harmine-derivatized AnnH-75 inhibitor
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Categories: Dual-specificity kinase | Human | Large Structures | Arrowsmith, C H | Bountra, C | Bracher, F | Chaikuad, A | Delft, F von | Edwards, A M | Knapp, S | Nowak, R | Structural genomic | Wurzlbauer, A | Down syndrome | Dyrk1a | Harmine | Inhibitor | Sgc | Transferase
