DNA ligase

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Human LigD IV contains several domains: DNA-binding domain (residues 1-240); adenylation domain (residues 268-405) and the ca. 100 amino acid long BRCT motifs (residues 654-911). In the ATP-dependent LigD the ATP binds between 2 symmetry related LigD molecules.
Human LigD IV contains several domains: DNA-binding domain (residues 1-240); adenylation domain (residues 268-405) and the ca. 100 amino acid long BRCT motifs (residues 654-911). In the ATP-dependent LigD the ATP binds between 2 symmetry related LigD molecules.
*<scene name='44/443730/Cv/4'>ATP binding site</scene> in ATP-dependent DNA ligase from ''S. solfataricus'' ([[2hix]]). <ref>PMID:17052461</ref>
*<scene name='44/443730/Cv/4'>ATP binding site</scene> in ATP-dependent DNA ligase from ''S. solfataricus'' ([[2hix]]). <ref>PMID:17052461</ref>
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== 3D Structures of DNA ligase ==
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[[DNA ligase 3D structures]]
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</StructureSection>
</StructureSection>
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**[[4eq5]] – LigD + AMP – ''Thermococcus sibiricus''<br />
**[[4eq5]] – LigD + AMP – ''Thermococcus sibiricus''<br />
**[[4d05]] – LigD + AMP - ''Psychromonas'' <br />
**[[4d05]] – LigD + AMP - ''Psychromonas'' <br />
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**[[6nhx]], [[6nhz]] – MtLigD D + ATP - ''Mycobacterium tuberculosis'' <br />
*NAD+-dependent LigD
*NAD+-dependent LigD
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**[[3ba8]], [[3ba9]], [[3baa]], [[3bab]], [[3bac]], [[4eeq]], [[4efb]], [[4efe]], [[4lh6]], [[4lh7]] - EfLigD adenylation domain + NMN + inhibitor – ''Enterococcus faecalis''<br />
**[[3ba8]], [[3ba9]], [[3baa]], [[3bab]], [[3bac]], [[4eeq]], [[4efb]], [[4efe]], [[4lh6]], [[4lh7]] - EfLigD adenylation domain + NMN + inhibitor – ''Enterococcus faecalis''<br />
**[[1ta8]], [[1tae]] - EfLigD adenylation domain<br />
**[[1ta8]], [[1tae]] - EfLigD adenylation domain<br />
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**[[1zau]] - MtLigD adenylation domain – ''Mycobacterium tuberculosis''<br />
+
**[[1zau]] - MtLigD adenylation domain <br />
**[[3sgi]] – MtLigD (mutant) + AMP<br />
**[[3sgi]] – MtLigD (mutant) + AMP<br />
**[[1v9p]], [[1dgs]] – LigD – ''Thermos filiformis''<br />
**[[1v9p]], [[1dgs]] – LigD – ''Thermos filiformis''<br />
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**[[2q2t]] – CvLigD + DNA + AMP + CMP – Chlorella virus<br />
**[[2q2t]] – CvLigD + DNA + AMP + CMP – Chlorella virus<br />
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**[[6imj]], [[6imk]], [[6iml]], [[6imn]] – LigD + DNA – African swine fever virus<br />
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**[[6gdr]] – LigD + DNA – ''Alteromonas mediterranea''<br />
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**[[6dt1]] – T4LigD + DNA – phage T4<br />
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**[[5wfy]] – T4LigD DNA-binding domain <br />
**[[2q2u]], [[ 1p8l]], [[ 1fvi]] - CvLigD + DNA + mononucleotide<br />
**[[2q2u]], [[ 1p8l]], [[ 1fvi]] - CvLigD + DNA + mononucleotide<br />
**[[2owo]] – LigD + DNA + AMP + CMP – ''Escherichia coli''<br />
**[[2owo]] – LigD + DNA + AMP + CMP – ''Escherichia coli''<br />
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**[[3w5o]] - hLigD IV <br />
**[[3w5o]] - hLigD IV <br />
**[[2e2w]] - hLigD IV BRCT domain - NMR<br />
**[[2e2w]] - hLigD IV BRCT domain - NMR<br />
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**[[1z56]] – LigD IV + ligase interacting factor 1 - yeast<br />
 
**[[3vnn]] - hLigD IV adenylation domain<br />
**[[3vnn]] - hLigD IV adenylation domain<br />
**[[4hto]] - hLigD IV DNA-binding domain<br />
**[[4hto]] - hLigD IV DNA-binding domain<br />
**[[4htp]] - hLigD IV DNA-binding domain + artemis protein peptide<br />
**[[4htp]] - hLigD IV DNA-binding domain + artemis protein peptide<br />
**[[3w1b]], [[3w1g]] - hLigD IV adenylation and DNA-binding domains + artemis protein peptide<br />
**[[3w1b]], [[3w1g]] - hLigD IV adenylation and DNA-binding domains + artemis protein peptide<br />
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**[[6bkg]], [[6bkf]] - hLigD IV + DNA<br />
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**[[1z56]] – LigD IV + ligase interacting factor 1 - yeast<br />
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}}
}}

Revision as of 07:40, 12 June 2019

ATP-dependent DNA ligase complexed with ATP 2hix

Drag the structure with the mouse to rotate

3D Structures of DNA ligase

Updated on 12-June-2019

References

  1. ↑ Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T. A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell. 2006 Oct 20;24(2):279-91. PMID:17052461 doi:10.1016/j.molcel.2006.08.015

Elevated expression of DNA ligase I in human cancers., Sun DY, Urrabaz R, Nguyen M, Marty J, Stringer S, Cruz E, Medina-Gundrum L, Weitman S., Clinical Cancer Research. 2001; 7(12):4143-4148.
Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene., Harrison C, Ketchen AM, Redhead NJ, O'Sullivan MJ, Melton DW., Cancer Research. 2002; 62(14):4065-4074.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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