DNA ligase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:41, 12 June 2019) (edit) (undo)
 
Line 24: Line 24:
</StructureSection>
</StructureSection>
- 
-
== 3D Structures of DNA ligase ==
 
- 
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
-
{{#tree:id=OrganizedByTopic|openlevels=0|
 
- 
-
*ATP-dependent LigD
 
- 
-
**[[3p4h]], [[3ta5]], [[3ta7]] – LigD N-terminal – ''Candidatus korarchaeum cryptofilum''<br />
 
-
**[[3gde]] – LigD – ''Archaeoglobus fulgidus''<br />
 
-
**[[2hiv]] – SsLigD – ''Sulfolobus solfataricus''<br />
 
-
**[[2hix]] - SsLigD + ATP<br />
 
-
**[[2cfm]] - LigD + AMP – ''Pyrococcus furiosus''<br />
 
-
**[[2fao]] - PaLigD polymerase domain – ''Pseudomonas aeruginosa''<br />
 
-
**[[2faq]], [[2far]] - PaLigD polymerase domain + ATP + Mn<br />
 
-
**[[1a0i]] – LigD (mutant) + ATP – Bacteriophage T7<br />
 
-
**[[4eq5]] – LigD + AMP – ''Thermococcus sibiricus''<br />
 
-
**[[4d05]] – LigD + AMP - ''Psychromonas'' <br />
 
-
**[[6nhx]], [[6nhz]] – MtLigD D + ATP - ''Mycobacterium tuberculosis'' <br />
 
- 
-
*NAD+-dependent LigD
 
- 
-
**[[3jsl]], [[3jsn]] - SaLigD adenylation domain – ''Staphylococcus aureus''<br />
 
-
**[[4cc5]], [[4cc6]], [[5fpo]], [[5fpr]] – SaLigD adenylation domain + inhibitor <br />
 
-
**[[3ba8]], [[3ba9]], [[3baa]], [[3bab]], [[3bac]], [[4eeq]], [[4efb]], [[4efe]], [[4lh6]], [[4lh7]] - EfLigD adenylation domain + NMN + inhibitor – ''Enterococcus faecalis''<br />
 
-
**[[1ta8]], [[1tae]] - EfLigD adenylation domain<br />
 
-
**[[1zau]] - MtLigD adenylation domain <br />
 
-
**[[3sgi]] – MtLigD (mutant) + AMP<br />
 
-
**[[1v9p]], [[1dgs]] – LigD – ''Thermos filiformis''<br />
 
-
**[[1b04]] – LigD adenylation domain (mutant) – ''Geobacillus stearothermophilus''<br />
 
-
**[[4glw]] – LigD A + NMN + inhibitor – ''Streptococcus pneumoniae''<br />
 
-
**[[4glx]] – EcLigD + DNA + inhibitor - ''Escherichia coli''<br />
 
-
**[[5tt5]] - EciLigD + NAD<br />
 
-
**[[3pn1]], [[4uco]], [[4ucr]], [[4ucs]], [[4uct]], [[4ucu]], [[4ucv]], [[4ufz]] – HiLigD adenylation domain + inhibitor – Haemophilus influenza<br />
 
-
**[[3uq8]] - HiLigD adenylation domain + NAD<br />
 
- 
-
*LigD
 
- 
-
**[[2q2t]] – CvLigD + DNA + AMP + CMP – Chlorella virus<br />
 
-
**[[6imj]], [[6imk]], [[6iml]], [[6imn]] – LigD + DNA – African swine fever virus<br />
 
-
**[[6gdr]] – LigD + DNA – ''Alteromonas mediterranea''<br />
 
-
**[[6dt1]] – T4LigD + DNA – phage T4<br />
 
-
**[[5wfy]] – T4LigD DNA-binding domain <br />
 
-
**[[2q2u]], [[ 1p8l]], [[ 1fvi]] - CvLigD + DNA + mononucleotide<br />
 
-
**[[2owo]] – LigD + DNA + AMP + CMP – ''Escherichia coli''<br />
 
-
**[[3qwu]] – LigD – ''Aquifex aeolicus''<br />
 
-
**[[1l7b]] – LigD BRCT domain – ''Thermos thermophilus'' - NMR<br />
 
-
**[[3rr5]] – LigD - ''Thermococcus''<br />
 
-
**[[5frq]] - LigD + DNA polymerase III subunit β – ''Helicobacter pylori''<br />
 
- 
-
*Mammalian LigD I
 
- 
-
**[[1x9n]] – hLigD I + DNA + AMP + CMP – human<br />
 
-
**[[2od8]] – LigD I residues 32-53 + PCNA
 
- 
-
*Mammalian LigD III
 
- 
-
**[[3l2p]] – hLigD III residues 257-833 + DNA<br />
 
-
**[[1uw0]] - hLigD III zinc-finger domain residues 1-117 – NMR<br />
 
-
**[[1imo]], [[1in1]] - hLigD III BRCTdomain – NMR<br />
 
-
**[[3pc7]] - hLigD III BRCTdomain<br />
 
-
**[[3pc8]] - hLigD III BRCTdomain (mutant) + XRCC1<br />
 
-
**[[3qvg]] - hLigD III BRCTdomain + XRCC1
 
- 
-
*Mammalian LigD IV
 
- 
-
**[[3ii6]], [[ 1ik9]] – hLigD IV C-terminal BRCT domains + DNA repair protein XRCC4<br />
 
-
**[[3w5o]] - hLigD IV <br />
 
-
**[[2e2w]] - hLigD IV BRCT domain - NMR<br />
 
-
**[[3vnn]] - hLigD IV adenylation domain<br />
 
-
**[[4hto]] - hLigD IV DNA-binding domain<br />
 
-
**[[4htp]] - hLigD IV DNA-binding domain + artemis protein peptide<br />
 
-
**[[3w1b]], [[3w1g]] - hLigD IV adenylation and DNA-binding domains + artemis protein peptide<br />
 
-
**[[6bkg]], [[6bkf]] - hLigD IV + DNA<br />
 
-
**[[1z56]] – LigD IV + ligase interacting factor 1 - yeast<br />
 
- 
-
}}
 
== References ==
== References ==

Current revision

ATP-dependent DNA ligase complexed with ATP 2hix

Drag the structure with the mouse to rotate

References

  1. ↑ Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T. A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell. 2006 Oct 20;24(2):279-91. PMID:17052461 doi:10.1016/j.molcel.2006.08.015

Elevated expression of DNA ligase I in human cancers., Sun DY, Urrabaz R, Nguyen M, Marty J, Stringer S, Cruz E, Medina-Gundrum L, Weitman S., Clinical Cancer Research. 2001; 7(12):4143-4148.
Replication failure, genome instability, and increased cancer susceptibility in mice with a point mutation in the DNA ligase I gene., Harrison C, Ketchen AM, Redhead NJ, O'Sullivan MJ, Melton DW., Cancer Research. 2002; 62(14):4065-4074.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/DNA_ligase"
Personal tools